FAM60A Antikörper (AA 1-221)

Produktnummer ABIN7868850

Der Kaninchen Polyklonal anti-FAM60A Antikörper wird verwendet zum Nachweis von FAM60A in Proben von Human und Ratte. Er wurde validiert für ELISA, WB, IF, FACS und IHC (p).

Kurzübersicht für FAM60A Antikörper (AA 1-221) (ABIN7868850)

Target: FAM60A (Family with Sequence Similarity 60, Member A (FAM60A))

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FAM60A Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-FAM60A Antikörper

Bindungsspezifität: AA 1-221

Verwendungszweck: FAM60A Antibody / SINHCAF

Aufreinigung: Antigen affinity purified

Immunogen: E. coli-derived recombinant human protein (amino acids M1-W221) was used as the immunogen for the FAM60A antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the FAM60A antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the FAM60A antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu FAM60A

Target: FAM60A (Family with Sequence Similarity 60, Member A (FAM60A))

Andere Bezeichnung: FAM60A

Hintergrund: FAM60A, also known as Protein FAM60A, Tera protein homolog and SIN3-HDAC complex-associated factor (SINHCAF), is a subunit of the Sin3 deacetylase complex (Sin3/HDAC) that is important for the repression of genes. The SIN3A-HDAC complex deacetylates histones thereby repressing gene transcription. FAM60A specifically impacts genes encoding components of the TGF-beta signaling pathway and promoters of important proteins like cyclin D1. FAM60A activity peaks during G1 and S phases of the cell cycle and is up regulated in many carcinoma and tumor tissues. Additionally, loss of FAM60A leads to a change in cell morphology, an increase in cell migration, increased histone acetylation at the cyclin D1 promoter and elevated levels of cyclin D1 mRNA and protein. Furthermore, depletion of FAM60A altered the periodic association of HDAC1 with the cyclin D1 promoter, increased cyclin D1 expression at all cell cycle phases, and caused premature S phase entry.

UniProt: Q9NP50