TFAM Antikörper (AA 1-200)

Produktnummer ABIN7868775

Der Maus Monoklonal anti-TFAM Antikörper wird verwendet zum Nachweis von TFAM in Proben von Human. Er wurde validiert für WB und IHC (p).

Kurzübersicht für TFAM Antikörper (AA 1-200) (ABIN7868775)

Target: TFAM (Transcription Factor A, Mitochondrial (TFAM))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser TFAM Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: TFAM-9713

Produktdetails anti-TFAM Antikörper

Bindungsspezifität: AA 1-200

Verwendungszweck: mtTFA Antibody | Mitochondrial transcription factor 1 / TFAM

Aufreinigung: Protein A/G affinity

Immunogen: A portion of amino acids 1-200 from human Mitochondrial transcription factor 1 protein was used as the immunogen for the mtTFA antibody.

Isotyp: IgG, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the mtTFA antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the mtTFA antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu TFAM

Target: TFAM (Transcription Factor A, Mitochondrial (TFAM))

Andere Bezeichnung: mtTFA

Hintergrund: MtTFA (mitochondrial transcription factor A), also known as mtTF1, TFAM, TCF6 (for transcription factor 6-like1), TCF6L2 and tsHMG, is a nuclear-encoded gene product that is imported into the mitochondria. mtTFA is required for many aspects of mitochondrial biogenesis including the replication and transcription of mitochondrial DNA (mtDNA). In mouse, testis-specific mtTFA is missing the mitochondria targeting sequence and is present in the nucleus rather than the mitochondria. This form of mtTFA is located primarily in the nuclei of elongated spermatids and may be involved in the regulation of gene expression of the haploid male genome. During mouse and human spermatogenesis there is a reduction of mtTFA protein levels and a reduction in mtDNA copy number. These features may provide one of the mechanisms by which paternal mtDNA transmission is prevented. mtTFA has been associated with mitochondrial disorder in humans characterized by ocular myopathy, exercise intolerance and muscle wasting.

UniProt: Q00059

Pathways: Chromatin Binding