KNG1 Antikörper (AA 1-200)

Produktnummer ABIN7868632

Der Maus Monoklonal anti-KNG1 Antikörper (Klon KNG1-7423) (ABIN7868632) detektiert spezifisch KNG1 in IHC (p). Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für KNG1 Antikörper (AA 1-200) (ABIN7868632)

Target: KNG1 (Kininogen 1 (KNG1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser KNG1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Güteklasse: Carrier-free

Klon: KNG1-7423

Produktdetails anti-KNG1 Antikörper

Bindungsspezifität: AA 1-200

Verwendungszweck: Kininogen 1 Antibody / KNG1 / Bradykinin (azide and preservative free)

Aufreinigung: Protein A/G affinity

Immunogen: A recombinant partial protein sequence (within amino acids 1-200) from the human protein was used as the immunogen for the Kininogen 1 antibody.

Isotyp: IgG1, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the Kininogen 1 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the Kininogen 1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu KNG1

Target: KNG1 (Kininogen 1 (KNG1))

Andere Bezeichnung: Kininogen 1

Hintergrund: Kininogen is a 644 amino acid precursor protein that is expressed by the KNG1 gene and is secreted into blood plasma. Due to alternative splicing events, several Kininogen protein derivatives exist, including Kininogen LC and Kininogen HC, both of which are produced from the Kininogen precursor and exhibit different functions throughout the cell. Kininogen HC plays an important role in blood coagulation by helping to ensure that prekallikrein and Factor XI (both of which are involved in blood coagulation) are properly situated for interaction with Factor XII. Kininogen HC releases a smaller, active protein known as bradykinin, which plays a role in smooth muscle contraction, induction of hypotension, regulation of blood glucose levels, stimulation of nociceptors and overall mediation of inflammatory responses throughout the cell. In contrast to Kininogen HC, which is involved in blood clotting, Kininogen LC is primarily associated with inhibition of thrombocyte aggregation and also functions as a strong inhibitor of cysteine proteinases.

UniProt: P01042

Pathways: ACE Inhibitor Pathway, Glycosaminoglycan Metabolic Process