KNG1 Antikörper (AA 1-200)

Produktnummer ABIN7868631

Der Maus Monoklonal anti-KNG1 Antikörper wird verwendet zum Nachweis von KNG1 in Proben von Human. Er wurde validiert für IHC (p).

Kurzübersicht für KNG1 Antikörper (AA 1-200) (ABIN7868631)

Target: KNG1 (Kininogen 1 (KNG1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser KNG1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: KNG1-7424

Produktdetails anti-KNG1 Antikörper

Bindungsspezifität: AA 1-200

Verwendungszweck: Bradykinin Antibody / KNG1 / Kininogen 1

Aufreinigung: Protein A/G affinity

Immunogen: A recombinant partial protein sequence (within amino acids 1-200) from the human protein was used as the immunogen for the Bradykinin antibody.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the Bradykinin antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the Bradykinin antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu KNG1

Target: KNG1 (Kininogen 1 (KNG1))

Andere Bezeichnung: Bradykinin

Hintergrund: Kininogen is a 644 amino acid precursor protein that is expressed by the KNG1 gene and is secreted into blood plasma. Due to alternative splicing events, several Kininogen protein derivatives exist, including Kininogen LC and Kininogen HC, both of which are produced from the Kininogen precursor and exhibit different functions throughout the cell. Kininogen HC plays an important role in blood coagulation by helping to ensure that prekallikrein and Factor XI (both of which are involved in blood coagulation) are properly situated for interaction with Factor XII. Kininogen HC releases a smaller, active protein known as bradykinin, which plays a role in smooth muscle contraction, induction of hypotension, regulation of blood glucose levels, stimulation of nociceptors and overall mediation of inflammatory responses throughout the cell. In contrast to Kininogen HC, which is involved in blood clotting, Kininogen LC is primarily associated with inhibition of thrombocyte aggregation and also functions as a strong inhibitor of cysteine proteinases.

UniProt: P01042

Pathways: ACE Inhibitor Pathway, Glycosaminoglycan Metabolic Process