LMO2 Antikörper (AA 1-159)

Produktnummer ABIN7868222

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch LMO2 in WB und IHC (p). Es zeigt Reaktivität gegenüber Proben von Zebrafisch (Danio rerio).

Kurzübersicht für LMO2 Antikörper (AA 1-159) (ABIN7868222)

Target: LMO2 (LIM Domain Only 2 (Rhombotin-Like 1) (LMO2))

Reaktivität: Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser LMO2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-LMO2 Antikörper

Bindungsspezifität: AA 1-159

Verwendungszweck: Danre Lmo2 Antibody / Rhombotin 2

Aufreinigung: Antigen affinity chromatography

Immunogen: E. coli-derived Danre Lmo2 recombinant protein (amino acids M1-V159) was used as the immunogen for the Danre Lmo2 antibody.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the Danre Lmo2 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the Danre Lmo2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu LMO2

Target: LMO2 (LIM Domain Only 2 (Rhombotin-Like 1) (LMO2))

Andere Bezeichnung: Lmo2

Hintergrund: Lmo2, or LIM domain only protein two, is a transcriptional regulator that plays a critical role in hematopoietic and vascular development. In zebrafish, Lmo2 is essential for the specification of blood and endothelial lineages and is widely used as a molecular marker for early hematopoietic progenitor cells.

Lmo2 does not directly bind to DNA but functions as a scaffold protein, forming complexes with other transcription factors to regulate gene expression. During zebrafish embryogenesis, Lmo2 is expressed in the intermediate cell mass, the site of primitive blood cell formation, and in the developing vasculature. It is required for the emergence of both erythroid and myeloid lineages, as well as for the proper development of endothelial cells.

Loss of Lmo2 function in zebrafish results in severe defects in blood cell formation and vascular patterning, highlighting its central role in mesodermal differentiation. Because of its strong evolutionary conservation and defined expression patterns, zebrafish Lmo2 serves as a powerful model for studying hematopoiesis, angiogenesis, and transcriptional networks involved in early development.

Lmo2 is also relevant to human health, as misregulation of Lmo2 has been associated with leukemia. This makes zebrafish Lmo2 a valuable tool in both basic research and disease modeling related to blood development and cancer biology.

UniProt: Q9PTJ3

Pathways: Chromatin Binding