Vinculin Antikörper (AA 1-149)

Produktnummer ABIN7868181

Der Kaninchen Polyklonal anti-Vinculin Antikörper wird verwendet zum Nachweis von Vinculin in Proben von Human, Maus, Ratte und Affe. Er wurde validiert für WB, ELISA, IF, IHC (p) und FACS.

Kurzübersicht für Vinculin Antikörper (AA 1-149) (ABIN7868181)

Target: Vinculin (VCL)

Reaktivität: Human, Maus, Ratte, Affe

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Vinculin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Produktdetails anti-Vinculin Antikörper

Bindungsspezifität: AA 1-149

Verwendungszweck: Vinculin Antibody / VCL

Aufreinigung: Affinity purified

Immunogen: Recombinant human protein (amino acids M1-E149) was used as the immunogen for the Vinculin antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the Vinculin antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the Vinculin antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu Vinculin

Target: Vinculin (VCL)

Andere Bezeichnung: Vinculin

Hintergrund: In mammalian cells, vinculin is a membrane-cytoskeletal protein in focal adhesion plaques that is involved in linkage of integrin adhesion molecules to the actin cytoskeleton. It is mapped to 10q22.2. Vinculin is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane. Defects in VCL are the cause of cardiomyopathy dilated type 1W. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined.

UniProt: P18206

Pathways: Cell-Cell Junction Organization, Maintenance of Protein Location, Signaling Events mediated by VEGFR1 and VEGFR2