Iba1 Antikörper (AA 1-146)

Produktnummer ABIN7868167

Der Maus Monoklonal anti-Iba1 Antikörper (Klon AIF1-2493) (ABIN7868167) detektiert spezifisch Iba1 in IHC (p). Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für Iba1 Antikörper (AA 1-146) (ABIN7868167)

Target: Iba1 (IBA1) (Ionized Calcium-binding Adapter Molecule 1 (IBA1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Iba1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: AIF1-2493

Produktdetails anti-Iba1 Antikörper

Bindungsspezifität: AA 1-146

Verwendungszweck: AIF1 Antibody / IBA1

Aufreinigung: Protein G affinity chromatography

Immunogen: A portion of amino acids 1-146 from the human protein was used as the immunogen for the AIF1 antibody.

Isotyp: IgG2c, kappa

Anwendungsinformationen

Applikationshinweise: Titering of the AIF1 antibody may be required for optimal performance.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store the AIF1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Details zu Iba1

Target: Iba1 (IBA1) (Ionized Calcium-binding Adapter Molecule 1 (IBA1))

Andere Bezeichnung: AIF1

Hintergrund: AIF1 (Allograft inflammatory factor 1), also called IBA1 (Ionized calcium-binding adapter molecule 1) is a cytoplasmic, calcium-binding protein that is thought to play a role in macrophage activation and function. AIF1/IBA1, containing two EF domains, is induced by cytokines and Interferons. In an unstimulated state, it colocalizes with actin, and upon stimulation, translocates to lamellipodia. It is also a marker of human microglia and is expressed by macrophages in injured skeletal muscle. The gene encoding the protein resides in the tumor necrosis factor (TNF) cluster of genes, located in the region represented by the human major histocompatibility complex (MHC).

UniProt: P55008

Pathways: Smooth Muscle Cell Migration