beta Amyloid Antikörper (AA 1-100, AA 8-16)

Produktnummer ABIN7867901

Dieser Maus Monoklonal Antikörper detektiert spezifisch beta Amyloid in IHC (p). Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für beta Amyloid Antikörper (AA 1-100, AA 8-16) (ABIN7867901)

Target: beta Amyloid (Abeta) (Amyloid beta (Abeta))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser beta Amyloid Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Güteklasse: Carrier-free

Klon: APP-4469

Produktdetails anti-beta Amyloid Antikörper

Bindungsspezifität: AA 1-100, AA 8-16

Verwendungszweck: Beta Amyloid Antibody / APP (azide and preservative free)

Aufreinigung: Protein A/G affinity

Immunogen: A portion of amino acids 1-100 of the amyloid beta protein was used as the immunogen for the Beta Amyloid antibody. This antibody recognizes an epitope in the region of amino acids 8-16 of the amyloid precursor protein.

Isotyp: IgG1, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the Beta Amyloid antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the Beta Amyloid antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu beta Amyloid

Target: beta Amyloid (Abeta) (Amyloid beta (Abeta))

Andere Bezeichnung: Beta Amyloid

Hintergrund: Proteolytic cleavage of the Amyloid protein precursor (APP) gives rise to the b-Amyloid and Amyloid A4 proteins, which are present in human platelets. Amyloid deposition is associated with type II diabetes, Down syndrome and a variety of neurological disorders, including Alzheimer s disease. The Amyloid precursor protein (APP) undergoes alternative splicing, resulting in several isoforms. Proteolytic cleavage of APP leads to the formation of the 4 kDa Amyloid b/A4 Amyloid protein. This protein is involved in the formation of neurofibrillary tangles and plaques that characterize the senile plaques of Alzheimer s patients. APLP1 (Amyloid precursor-like protein 1) and APLP2 are structurally similar to APP. Human APLP2 is a membrane-bound sperm protein that contains a region highly homologous to the transmembrane-cytoplasmic domains of APP found in brain plaques of Alzheimer s disease patients.

UniProt: P05067

Pathways: Inflammasome