MCM3 Antikörper (AA 650-750)

Produktnummer ABIN7865520

Der Maus Monoklonal anti-MCM3 Antikörper (Klon MSVA-503M) (ABIN7865520) detektiert spezifisch MCM3 in IHC. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für MCM3 Antikörper (AA 650-750) (ABIN7865520)

Target: MCM3 (Minichromosome Maintenance Complex Component 3 (MCM3))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser MCM3 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Klon: MSVA-503M

Produktdetails anti-MCM3 Antikörper

Bindungsspezifität: AA 650-750

Verwendungszweck: MCM3 (Proliferation Marker) Antibody

Spezifität: Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for DNA replication and cell proliferation.

Aufreinigung: Ab produced in CHO cell mammalian-based expression system.

Immunogen: Recombinant fragment (aa 650-750) of human MCM3 protein (exact sequence is proprietary)

Isotyp: IgG1, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Details zu MCM3

Target: MCM3 (Minichromosome Maintenance Complex Component 3 (MCM3))

Andere Bezeichnung: MCM3

Hintergrund:

Cervical cancer proto-oncogene 5, DNA polymerase alpha holoenzyme-associated protein P1, DNA replication factor MCM3, DNA replication licensing factor mcm3, HCC5, hRlf beta subunit, Human cervical cancer proto oncogene 5, MGC1157, Minichromosome maintenance complex component 3, Minichromosome maintenance deficient 3, P102 protein, Replication licensing factor beta subunit, RLF beta subunit, RLF subunit beta

Colon: A strong nuclear MCM3 immunostaining should be seen in virtually all crypt base cells.

Molekulargewicht: 115kDa

Gen-ID: 4172, 179565

UniProt: P25205

Pathways: DNA Reparatur, Mitotic G1-G1/S Phases, DNA Replication, Chromatin Binding, Synthesis of DNA