WTAP Antikörper

Produktnummer ABIN7862278

Der Maus Monoklonal anti-WTAP Antikörper (Klon PCRP-WTAP-1A4) (ABIN7862278) detektiert spezifisch WTAP in IHC und FACS. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für WTAP Antikörper (ABIN7862278)

Target: WTAP (Wilms Tumor 1 Associated Protein (WTAP))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser WTAP Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Flow Cytometry (FACS)

Klon: PCRP-WTAP-1A4

Produktdetails anti-WTAP Antikörper

Verwendungszweck: WTAP Antibody

Spezifität: Wilms tumor (WT) is an embryonal malignancy of the kidney that affects 1 in 10,000 infants and is observed in both sporadic and inherited forms. The Wilms tumor protein (WT1) binds the DNA sequence GCGGGGGCG, a recognition element common to the early growth response (Egr) family of Zn2+ finger transcriptional activators, and functions as a transcriptional repressor. WTAP (wilms tumor 1-associating protein) is a ubiquitously expressed nuclear protein that interacts with WT1 and may be involved in regulating mRNA splicing. WTAP is found in nuclear speckles, where it regulates the G2/M cell cycle transition by binding to the 3' UTR of cyclin A2, thus enhancing its stability. Additionally, WTAP inhibits expression of WT1 target genes and is able to impair the ability of WT1 to bind DNA. Two isoforms of WTAP exist due to alternative splicing events.

Aufreinigung: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant full-length human WTAP protein

Isotyp: IgG2b, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Konservierungsmittel: Azide free

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Haltbarkeit: 24 months

Details zu WTAP

Target: WTAP (Wilms Tumor 1 Associated Protein (WTAP))

Andere Bezeichnung: WTAP

Hintergrund:

Female-lethal(2)D homolog, hFL(2)D, PNAS132, Pre-mRNA-splicing regulator WTAP, Putative pre mRNA splicing regulator female lethal(2D), Wilms' tumour 1-associating protein, WT1 associated protein

Ubiquitous expression.

Molekulargewicht: 44.2kDa

Gen-ID: 9589, 446091

UniProt: Q15007