TMPRSS2 Antikörper

Produktnummer ABIN7864531

Der Maus Monoklonal anti-TMPRSS2 Antikörper (Klon TMPRSS2-7420) (ABIN7864531) detektiert spezifisch TMPRSS2 in IHC. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für TMPRSS2 Antikörper (ABIN7864531)

Target: TMPRSS2 (Transmembrane Protease, serine 2 (TMPRSS2))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser TMPRSS2 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Klon: TMPRSS2-7420

Produktdetails anti-TMPRSS2 Antikörper

Verwendungszweck: TMPRSS2 (Transmembrane Serine Protease 2) Antibody

Spezifität: Extracellular proteases mediate the digestion of neighboring extracellular matrix components in initial tumor growth, allow desquamation of tumor cells into the surrounding environment, provide the basis for invasion of basement membranes in targeted metastatic organs and are required for release and activation of many growth and angiogenic factors. The TMPRSS2 gene encodes a 492 amino acid multimeric serine protease, which is mainly expressed in the mouse prostate and kidney, and is also expressed in the human small intestine, prostate, colon, stomach and salivary gland. TMPRSS2 contains several domains, including a serine protease domain of the S1 family, a scavenger receptor cysteine-rich domain of group A, an LDL receptor class A domain and a transmembrane domain. TMPRSS2 is expressed as a full length form and a cleaved protease domain and its expression is increased by androgenic hormones. TMPRSS2 is also expressed in prostate carcinoma, suggesting that it may play a role in prostate carcinogenesis.

Aufreinigung: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant full-length human TMPRSS2 protein (exact sequence is proprietary)

Isotyp: IgG1, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Details zu TMPRSS2

Target: TMPRSS2 (Transmembrane Protease, serine 2 (TMPRSS2))

Andere Bezeichnung: TMPRSS2

Hintergrund:

D16Ertd61e, Epitheliasin, FLJ41954, MGC6821, PP9284, PRSS10, Serine protease 10, TMPRSS2 ETV1 FUSION GENE, INCLUDED, Transmembrane protease serine 2 catalytic chain, Transmembrane protease, serine 2, EC 3.4.219

colon|Expressed strongly in small intestine. Also expressed in prostate|stomach and salivary gland.

Molekulargewicht: 70kDa

Gen-ID: 7113, 439309

UniProt: O15393

Pathways: SARS-CoV-2 Protein Interaktom