KDM5C Antikörper

Produktnummer ABIN7861649

Dieser Maus Monoklonal Antikörper detektiert spezifisch KDM5C in FACS. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für KDM5C Antikörper (ABIN7861649)

Target: KDM5C (Lysine (K)-Specific Demethylase 5C (KDM5C))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser KDM5C Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS)

Klon: PCRP-KDM5C-1A11

Produktdetails anti-KDM5C Antikörper

Verwendungszweck: KDM5C Antibody

Spezifität: SmcX, also known as JARID1C (jumonji, AT rich interactive domain 1C), MRXJ, KDM5C or XE169, is a nuclear protein that contains one ARID domain, one JmjC domain, one JmjN domain and two PHD-type zinc fingers and belongs to the JARID1 histone demethylase family. Expressed ubiquitously with highest expression in brain and skeletal muscle, SmcX functions as a histone demethylase that removes methyl groups from lysine residues on Histone H3, thereby playing a role in the histone code, as well as transcriptional regulation and chromatin remodeling. SmcX binds iron and a-ketoglutarate as cofactors and can recruit histone deacetylases to neuron silencer elements, thus repressing the transcription of neuronal genes. Defects in the gene encoding SmcX are associated with X-linked mental retardation (XLMR), a condition characterized by cognitive impairment and a low IQ. Multiple isoforms of SmcX are expressed due to alternative splicing events.

Aufreinigung: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant full-length human KDM5C protein

Isotyp: IgG2c

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Konservierungsmittel: Azide free

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Haltbarkeit: 24 months

Details zu KDM5C

Target: KDM5C (Lysine (K)-Specific Demethylase 5C (KDM5C))

Andere Bezeichnung: KDM5C

Hintergrund:

DXS1272E, JARID1C, MRX13, SMCX, XE169

HeLa cells.

Molekulargewicht: 176kDa

Gen-ID: 8242, 631768

UniProt: P41229

Pathways: Warburg Effekt