HES5 Antikörper

Produktnummer ABIN7865264

Dieser Maus Monoklonal Antikörper detektiert spezifisch HES5 in IHC. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für HES5 Antikörper (ABIN7865264)

Target: HES5 (Hairy and Enhancer of Split 5 (HES5))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser HES5 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Klon: HES5-8035

Produktdetails anti-HES5 Antikörper

Verwendungszweck: HES5 / bHLHb38 / Hes family bHLH transcription factor 5 Antibody

Spezifität: The Drosophila Hairy and Enhancer of split genes encode basic helix-loop-helix (bHLH) transcriptional repressors that function in the Notch signaling pathway and control segmentation and neural development during embryogenesis. The mammalian homologues of Drosophila Hairy and Enhancer of split are the HES gene family members, HES1-6, which also encode bHLH transcriptional repressors that regulate myogenesis and neurogenesis. The HES family members form a complex with TLE, the mammalian homologue of Groucho, and this interaction is mediated by the carboxy terminal WRPW motif of the HES proteins. The HES/TLE complex functions by directly binding to DNA, instead of interfering with activator proteins. Most HES family members, including HES1 and HES5, preferentially bind to the N box (CACNAG) as opposed to the E box (CANNTG). HES2 binds to both N and E box sites, while HES6 does not bind DNA. Rather, HES6 inhibits HES1 activity, thereby promoting transcription. HES1 and HES2 are expressed in a variety of adult and embryonic tissues. HES3 is expressed exclusively in cerebellar Purkinje cells, and HES5 is found solely in the nervous system. HES6 is produced in brain as well as in the limb buds of developing embryos.

Aufreinigung: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment of human HES5 protein (exact sequence is proprietary)

Isotyp: IgG2, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Antibody with azide - store at 4 to 8°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Haltbarkeit: 24 months

Details zu HES5

Target: HES5 (Hairy and Enhancer of Split 5 (HES5))

Andere Bezeichnung: HES5

Hintergrund: BHLHb38

Molekulargewicht: 41kDa

Gen-ID: 388585, 57971

UniProt: Q5TA89

Pathways: Stem Cell Maintenance, Tube Formation