AMH Antikörper (C-Term)

Produktnummer ABIN7862896

Der Maus Monoklonal anti-AMH Antikörper wird verwendet zum Nachweis von AMH in Proben von Human, Maus, Schaf und Pavian. Er wurde validiert für WB und IHC.

Kurzübersicht für AMH Antikörper (C-Term) (ABIN7862896)

Target: AMH (Anti-Mullerian Hormone (AMH))

Reaktivität: Human, Maus, Schaf, Pavian

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser AMH Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Klon: AMH-300

Produktdetails anti-AMH Antikörper

Bindungsspezifität: AA 460-560, C-Term

Verwendungszweck: Anti Mullerian Hormone (AMH) / Mullerian Inhibiting Substance (MIS) Antibody

Spezifität: The transforming growth factor æ(TGF æ) superfamily is composed of numerous growth and differentiation factors, including TGF æ1-3, Mullerian inhibiting substance (MIS), growth/differentiation factor (GDF) 1-9, bone morphogenic protein (BMP) 2-8, glial cell line-derived neurotrophic factor (GDNF), Inhibin °™, æ-A, æ-B and æ-C, Lefty and Nodal. Members of the TGF æsuperfamily are involved in embryonic development and adult tissue homeostasis. The MIS glycoprotein is produced by the Sertoli cells of the testes. Fetal testes produce both MIS and testosterone, the presence of which result in male offspring. Absence of MIS and testosterone in a developing fetus results in the induction of Mullerian duct differentiation, and Wolffian duct development is not induced. Testosterone induces the differentiation of the Wolffian ducts whereas MIS causes regression of the Muellerian duct. MIS inhibits the growth of tumors derived from tissues of Mullerian duct origin. MIS can also inhibit the autophosphorylation of the EGF receptor in vitro. Defects in anti-Muellerian hormone are the cause of persistent Muellerian duct syndrome type I (PMDS-1). PMDS-1 is a form of male pseudo hermaphroditism characterized by a failure of Muellerian duct regression in otherwise normal males.

Aufreinigung: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment of the C-terminus of human AMH (aa 460-560) (exact sequence is proprietary)

Isotyp: IgG1, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Haltbarkeit: 24 months

Details zu AMH

Target: AMH (Anti-Mullerian Hormone (AMH))

Andere Bezeichnung: Anti Mullerian Hormone

Hintergrund:

Muellerian inhibiting factor (MIF)

Human or mouse ovary tissue.

Molekulargewicht: 70kDa (reduced), 140kDa (nonreduced)

Gen-ID: 268, 112432

Pathways: Negative Regulation of Hormone Secretion