Rekombinanter MUM1 Antikörper (C-Term)

Produktnummer ABIN7860711

Der Kaninchen Monoklonal anti-MUM1 Antikörper wird verwendet zum Nachweis von MUM1 in Proben von Human. Er wurde validiert für IHC.

Kurzübersicht für Rekombinanter MUM1 Antikörper (C-Term) (ABIN7860711)

Target: MUM1 (Melanoma Associated Antigen (Mutated) 1 (MUM1))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser MUM1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Klon: MUM1-8560R

Produktdetails anti-MUM1 Antikörper

Bindungsspezifität: C-Term

Verwendungszweck: Recombinant MUM1 / IRF4 (Transcription Factor) Antibody

Spezifität: MUM1 is one of nuclear transcription factors necessary for development and activation of B lymphocytes. MUM1 belongs to the IRF gene family containing at least 10 widely expressed genes with similar DNA binding motif all involved in regulation of cell growth, transformation and induction of apoptosis as well as development of T-cell immune response. The synonym of MUM1 is Interferon Regulatory Factor 4 (IRF4). MUM1 is found mainly in B-cell lymphoma and melanocytic lesions. Significant variation in positivity mainly due to chromosomal translocations involving MUM1 gene among T-cell lymphomas is observed. MUM1 is useful in a panel with other markers for subclassification of malignant lymphomas and identification of plasma cell differentiation. Particularly MUM1 may be useful for the identification of plasma cell differentiation when morphologic evidence is lacking and Ig light chains are difficult to interpret.

Aufreinigung: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (corresponding to C-terminal) of IRF4 protein (exact sequence is proprietary)

Isotyp: IgG, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: Prepared in 10  mM PBS with 0.05 % azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody is stable for 24 months. ,Non-hazardous. No MSDS required.

Haltbarkeit: 24 months

Details zu MUM1

Target: MUM1 (Melanoma Associated Antigen (Mutated) 1 (MUM1))

Andere Bezeichnung: MUM1

Hintergrund:

Interferon regulatory factor 4, IRF 4, LSIRF, Lymphocyte specific interferon regulatory factor, Multiple myeloma oncogene 1, MUM1, NFEM5, PU.1 interaction partner, Sfpi1/PU.1 interaction partner, Transcriptional activator PIP

Human tonsil or diffuse large B-cell lymphoma (DLBCL).

Molekulargewicht: 52kDa

Gen-ID: 3662, 401013

UniProt: Q15306

Pathways: Chromatin Binding