Rekombinanter FTH1 Antikörper (AA 58-180)

Produktnummer ABIN7860399

Der Kaninchen Monoklonal anti-FTH1 Antikörper wird verwendet zum Nachweis von FTH1 in Proben von Human und Ratte. Er wurde validiert für WB und IHC.

Kurzübersicht für Rekombinanter FTH1 Antikörper (AA 58-180) (ABIN7860399)

Target: FTH1 (Ferritin, Heavy Polypeptide 1 (FTH1))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser FTH1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Klon: FTH-8700R

Produktdetails anti-FTH1 Antikörper

Bindungsspezifität: AA 58-180

Verwendungszweck: Recombinant Ferritin, Heavy Chain (FTH) (Microglia Marker) Antibody

Spezifität: Mammalian ferritins consist of 24 subunits made up of 2 types of poly-peptide chains, ferritin heavy chain and ferritin light chain, which each have unique functions. Ferritin heavy chains catalyze the first step in iron storage, the oxidationof FeI(II), whereas ferritin light chains promote the nucleation of ferrihydrite, enabling storage of Fe(III). The most prominent role of mammalian ferritins is to provide iron-buffering capacity to cells. In addition to iron buffering, heavy chain ferritin is also involved in the regulation of thymidine biosynthesis via increased expression of cytoplasmic serine hydroxymethyltransferase, which is a limiting factor in thymidylate synthesis in MCF-7 cells. Light chain ferritin is involved in cataracts by at least two mechanisms: hereditary hyperferritinemia cataract syndrome, in which light chain ferritin is overexpressed, and oxidative stress, an important factor in the development of aging-related cataracts.

Aufreinigung: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant human FTH1 protein fragment (around aa 58-180) (exact sequence is proprietary)

Isotyp: IgG, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Konservierungsmittel: Azide free

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Haltbarkeit: 24 months

Details zu FTH1

Target: FTH1 (Ferritin, Heavy Polypeptide 1 (FTH1))

Andere Bezeichnung: Ferritin, Heavy Chain

Hintergrund:

Apoferritin, Cell proliferation-inducing gene 15 protein, Ferritin H subunit, FHC, FRIH, FTH1, FTHL6, Iron overload autosomal dominant, PIG15, Placenta immunoregulatory factor, Proliferation inducing gene 15 protein (PLIF)

Human liver tissue. Liver tissue lysate, A-549, A-431, Human Brain, Rat Brain, Human Kidney, Rat Kidney, Human Lungs, Rat Lungs

Molekulargewicht: 21kDa

Gen-ID: 2495

UniProt: P02794

Pathways: Transition Metal Ion Homeostasis