FLT3 Antikörper (AA 500-800)

Produktnummer ABIN7860345

Der Maus Monoklonal anti-FLT3 Antikörper wird verwendet zum Nachweis von FLT3 in Proben von Human. Er wurde validiert für IHC.

Kurzübersicht für FLT3 Antikörper (AA 500-800) (ABIN7860345)

Target: FLT3 (Fms-Related tyrosine Kinase 3 (FLT3))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser FLT3 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Klon: FLT3-9887

Produktdetails anti-FLT3 Antikörper

Bindungsspezifität: AA 500-800

Verwendungszweck: Flt3 / CD135 (Marker of Acute Myeloid Leukemia) Antibody

Spezifität: Stem cell tyrosine kinase (STK-1) has been cloned from a CD34+ hematopoietic stem cell enriched library and identified as the human homolog of a previously identified gene of Mouse origin designated either Flk-2 or Flt-3. The STK-1 cDNA encodes a protein of 993 amino acids with 85 % identity to Flt-3/Flk-2. STK-1 is a member of the type III receptor tyrosine kinase family that includes Kit (steel factor receptor), Fms and PDGF. STK-1 expression in blood and marrow is restricted to CD34+ cells, a population greatly enriched for hematopoietic stem/progenitor cells. STK-1 antiserum recognizes two polypeptides in these cells. The Mouse homolog of STK-1, designated Flt-3/Flk-2, is expressed at high levels in hematopoietic cells and also in neural, gonadal, hepatic and placental tissues. It has been suggested that STK-1 and its murine homolog Flt-3/Flk-2 may function as growth factor receptors on hematopoietic stem and/or progenitor cells.

Aufreinigung: 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (around aa500-800) of human FLT3 protein (exact sequence is proprietary)

Isotyp: IgG2, lambda

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Konservierungsmittel: Azide free

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Haltbarkeit: 24 months

Details zu FLT3

Target: FLT3 (Fms-Related tyrosine Kinase 3 (FLT3))

Andere Bezeichnung: Flt3

Hintergrund:

CD135, CD135 antigen, Fetal liver kinase 2, FL cytokine receptor, Flk2, FLT-3, Flt3, FLT3_HUMAN, FMS like tyrosine kinase 3, Fms related tyrosine kinase 3, Growth factor receptor tyrosine kinase type III, Ly-72, OTTHUMP0000004234, Receptor type tyrosine protein kinase FLT3, Stem cell tyrosine kinase 1, Stk 1, STK-1, Stk1, Tyrosine protein kinase receptor FLT3,

Human brain, lymph node or MDAMB468 xenograft.

Molekulargewicht: 160kDa

Gen-ID: 2322, 507590

UniProt: P36888

Pathways: RTK Signalweg