SIGLEC10 Antikörper (AA 500-697)

Produktnummer ABIN7864583

Der Maus Monoklonal anti-SIGLEC10 Antikörper wird verwendet zum Nachweis von SIGLEC10 in Proben von Human. Er wurde validiert für IHC.

Kurzübersicht für SIGLEC10 Antikörper (AA 500-697) (ABIN7864583)

Target: SIGLEC10 (Sialic Acid Binding Ig-Like Lectin 10 (SIGLEC10))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser SIGLEC10 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Klon: SIGLEC10-7581

Produktdetails anti-SIGLEC10 Antikörper

Bindungsspezifität: AA 500-697

Verwendungszweck: SIGLEC10 Antibody

Spezifität: Siglec-10 (sialic acid-binding Ig-like lectin 10) is a 697 amino acid protein belonging to the immunoglobulin superfamily. The N-terminal Ig-like domain of Siglec-10 contains a sialic acid-binding site and the C-terminal cytoplasmic region of Siglec-10 contains two immunoreceptor tyrosine-based inhibitor motifs (ITIMs), which are involved in the modulation of cellular responses through SH2 domains. With most expression in spleen, bone marrow and peripheral blood lymphocytes, such as monocytes, natural killer cells and eosinophils, it is likely that Siglec-10 functions as an inhibitory receptor in the immune response. Importantly, Siglec-10 mRNA is found to be highly upregulated in eosinophils at sites of inflammation in asthmatics, suggesting that Siglec-10 may be an appropriate target for new approaches of immunomodulatory therapy. There are six named isoforms of Siglec-10 that are a result of alternative splicing. All isoforms exists as single-pass transmembrane proteins, except for isoform 6, which is secreted.

Aufreinigung: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (around aa500-697) of human SIGLEC10 protein (exact sequence is proprietary)

Isotyp: IgG2, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Details zu SIGLEC10

Target: SIGLEC10 (Sialic Acid Binding Ig-Like Lectin 10 (SIGLEC10))

Andere Bezeichnung: SIGLEC10

Hintergrund:

mSiglec G, PRO940, sialic acid binding Ig like lectin 10 Ig like lectin 7, Sialic acid binding Immunoglobulin like lectin 10, Siglec G, siglec like gene 2, Siglec like protein 2, Siglecg, SLG2

Expressed by peripheral blood leukocytes (eosinophils|lung|monocytes and a natural killer cell subpopulation). Isoform 5 is found in lymph node|ovary and appendix. Isoform 1 is found at high levels and isoform 2 at lower levels in bone marrow|spleen a

Molekulargewicht: 77kDa

Gen-ID: 89790, 284813

UniProt: Q96LC7