Rekombinanter Clusterin Antikörper (AA 410-440)

Produktnummer ABIN7860145

Der Kaninchen Monoklonal anti-Clusterin Antikörper (Klon CLU-9192R) (ABIN7860145) detektiert spezifisch Clusterin in WB und IHC. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für Rekombinanter Clusterin Antikörper (AA 410-440) (ABIN7860145)

Target: Clusterin (CLU)

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser Clusterin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Klon: CLU-9192R

Produktdetails anti-Clusterin Antikörper

Bindungsspezifität: AA 410-440

Verwendungszweck: Recombinant Clusterin / Apolipoprotein J (APO-J) Antibody

Spezifität: Clusterin, also designated complement lysis inhibitor (CLI), apolipoprotein J (APOJ), sulfated glycoprotein 2 (SGP2), SP40 and testosterone-repressed prostate message 2 (TRPM2), is a secretory, heterodimeric glycoprotein that influences immune regulation, cell adhesion, transformation, lipid transportation, tissue remodeling, membrane recycling and cell-cell interactions. Clusterin is synthesized as a 449 amino acid polypeptide that is post-translationally cleaved at an internal bond between Arg 227 and Ser 228. Two subunits, ± and ≤, are associated through disulfide bonds. The ≤ subunit (also called ApoJ±) corresponds to residues 23-227. The ± subunit (also called ApoJ≤) corresponds to residues 228-449. Overexpression of Clusterin appears to be more common in late stages of mammary tumor progression. Clusterin markedly influences ≤-Amyloid structure and neuritic toxicity in vivo and may influence Alzheimer s pathogenesis.

Aufreinigung: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (around aa410-440) of human CLU protein (exact sequence is proprietary)

Isotyp: IgG, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Konservierungsmittel: Azide free

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Details zu Clusterin

Target: Clusterin (CLU)

Andere Bezeichnung: Clusterin

Hintergrund:

Aging associated protein 4, Apolipoprotein J, CLU1, CLU2, Clusterin alpha / beta chain, Complement associated protein SP40, Complement cytolysis inhibitor a chain, NA1/NA2, D14Ucla3, Dimeric acid glycoprotein, GP80, Ku70-binding protein 1 (KUB1), Sulfated glycoprotein 2 (SGP2), Testosterone repressed prostate message 2 (TPRM2B)

Human pancreas, Brain, Liver |tonsil or cervix.

Molekulargewicht: 70kDa (precursor), 36-39kDa (é±), 34-36kDa (é≤)

Gen-ID: 1191, 436657

UniProt: P10909

Pathways: Apoptose, Negative Regulation of intrinsic apoptotic Signaling