IGKV1-27 Antikörper (AA 241-356)

Produktnummer ABIN7863458

Dieser Maus Monoklonal Antikörper detektiert spezifisch IGKV1-27 in IHC. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für IGKV1-27 Antikörper (AA 241-356) (ABIN7863458)

Target: IGKV1-27 (Immunoglobulin kappa Variable 1-27 (IGKV1-27))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser IGKV1-27 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Klon: TNFAIP3-2813

Produktdetails anti-IGKV1-27 Antikörper

Bindungsspezifität: AA 241-356

Verwendungszweck: A20 / TNFAIP3 (Marker of Tamoxifen Resistance) Antibody

Spezifität: A20 (also known as TNFAIP3) is a zinc finger protein and inhibits NF-kappa B activation as well as TNF-mediated apoptosis. The protein has both ubiquitin ligase and deubiquitinase activities, is involved in the cytokine-mediated immune and inflammatory responses. A20 is as a tumor suppressor and has been shown to protect MCF-7 breast carcinoma cells from TNF-induced apoptosis. HighA20expression levels were observed in more aggressive breast tumors (ER-negative, progesterone receptor-negative and high histological grade). These findings strongly suggest that A20 is a key protein involved in tamoxifen resistance.

Aufreinigung: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (around aa 241-356) of human TNFAIP3 protein (exact sequence is proprietary)

Isotyp: IgG2c, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Haltbarkeit: 24 months

Details zu IGKV1-27

Target: IGKV1-27 (Immunoglobulin kappa Variable 1-27 (IGKV1-27))

Andere Bezeichnung: A20

Hintergrund:

A20, Putative DNA-binding protein A20, TNF alpha-induced protein 3 (TNFAIP3), Tumor Necrosis Factor alpha-Induced Protein 3(TNFAIP3), Zinc finger protein A20

Hodgkin s Lymphoma or hepatocellular carcinoma (HCC).

Molekulargewicht: ~90kDa

Gen-ID: 7128, 211600

UniProt: P21580

Pathways: Activation of Innate immune Response