Fodrin (AA 2351-2475) Antikörper

Produktnummer ABIN7859608

Der Maus Monoklonal anti-Fodrin Antikörper (Klon SPTAN1-3374) (ABIN7859608) detektiert spezifisch Fodrin in ELISA. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für Fodrin (AA 2351-2475) Antikörper (ABIN7859608)

Target: Fodrin

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Unkonjugiert

Applikation: ELISA

Klon: SPTAN1-3374

Produktdetails

Bindungsspezifität: AA 2351-2475

Verwendungszweck: Fodrin / Alpha Spectrin II (SPTAN1) / NEAS Antibody

Spezifität: Spectrin, an actin binding protein that is a major component of the cytoskeletal superstructure of the erythrocyte plasma membrane, is essential in determining the properties of the membrane including its shape and deformability. Spectrins function as membrane organizers and stabilizers, composed of nonhomologous ± and ≤ chains, which aggregate side-to-side in an antiparallel fashion to form dimers, tetramers, and higher polymers. Spectrin ± I and spectrin ≤ I are present in erythrocytes, whereas spectrin ± II (also designated fodrin ±) and spectrin ≤ II (also designated fodrin ≤) are present in other somatic cells. The spectrin tetramers in erythrocytes act as barriers to lateral diffusion, but spectrin dimers seem to lack this function. Activation of calpain results in the breakdown of spectrin ± II, a neuronal cytoskeleton protein.

Aufreinigung: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment of human SPTAN1 protein (around aa2351-2475) (exact sequence is proprietary)

Isotyp: IgG2b, lambda

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Konservierungsmittel: Azide free

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Antigendetails

Target: Fodrin

Hintergrund:

Alpha-II spectrin, brain, EIEE5, Fodrin alpha chain, NEAS, Non erythrocytic spectrin alpha, non-erythroid alpha chain, SPECA, Spectrin alpha chain brain, Spectrin, alpha, non-erythrocytic 1 (alpha-fodrin), Spna2, SPTA2

Human colon or kidney tissues (IHC).

Molekulargewicht: 240kDa

Gen-ID: 6709, 372331

UniProt: Q13813