Fodrin (AA 2351-2475) Antikörper

Produktnummer ABIN7863429

Der Maus Monoklonal anti-Fodrin Antikörper wird verwendet zum Nachweis von Fodrin in Proben von Human. Er wurde validiert für IHC.

Kurzübersicht für Fodrin (AA 2351-2475) Antikörper (ABIN7863429)

Target: Fodrin

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Unkonjugiert

Applikation: Immunohistochemistry (IHC)

Klon: SPTAN1-3505

Produktdetails

Bindungsspezifität: AA 2351-2475

Verwendungszweck: Fodrin / Alpha Spectrin II (SPTAN1) / NEAS Antibody

Spezifität: Spectrin, an actin binding protein that is a major component of the cytoskeletal superstructure of the erythrocyte plasma membrane, is essential in determining the properties of the membrane including its shape and deformability. Spectrins function as membrane organizers and stabilizers, composed of nonhomologous °™ and æ chains, which aggregate side-to-side in an antiparallel fashion to form dimers, tetramers, and higher polymers. Spectrin °™ I and spectrin æ I are present in erythrocytes, whereas spectrin °™ II (also designated fodrin °™) and spectrin æ II (also designated fodrin æ) are present in other somatic cells. The spectrin tetramers in erythrocytes act as barriers to lateral diffusion, but spectrin dimers seem to lack this function. Activation of calpain results in the breakdown of spectrin °™ II, a neuronal cytoskeleton protein.

Aufreinigung: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment of human SPTAN1 protein (around aa2351-2475) (exact sequence is proprietary))

Isotyp: IgG2b, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Haltbarkeit: 24 months

Antigendetails

Target: Fodrin

Hintergrund:

Alpha-II spectrin, brain, EIEE5, Fodrin alpha chain, NEAS, Non erythrocytic spectrin alpha, non-erythroid alpha chain, SPECA, Spectrin alpha chain brain, Spectrin, alpha, non-erythrocytic 1 (alpha-fodrin), Spna2, SPTA2

Human colon or kidney tissues (IHC).

Molekulargewicht: 240kDa

Gen-ID: 6709, 372331

UniProt: Q13813