ERCC1 Antikörper (AA 191-281)

Produktnummer ABIN7859358

Der Maus Monoklonal anti-ERCC1 Antikörper wird verwendet zum Nachweis von ERCC1 in Proben von Human. Er wurde validiert für IHC.

Kurzübersicht für ERCC1 Antikörper (AA 191-281) (ABIN7859358)

Target: ERCC1 (Excision Repair Cross Complementing Polypeptide-1 (ERCC1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser ERCC1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Klon: ERCC1-7596

Produktdetails anti-ERCC1 Antikörper

Bindungsspezifität: AA 191-281

Verwendungszweck: ERCC1 / RAD10 (Tumor Progression Marker) Antibody

Spezifität: Recognizes a protein of 110 kDa, identified as Excision Repair Cross Complementing 1 (ERCC1). It is a mammalian nucleotide excision repair (NER) enzyme involved in repair of damaged DNA. ERCC1 is a homologous to RAD10 in Saccharomyces cerevisiae, which is required in mitotic intrachromosomal recombination and repair. ERCC1 is required in repair of cisplatin-induced DNA adducts and ultraviolet (UV)-induced DNA damage. High expression of ERCC1 has been linked to tumor progression in a variety of cancers including non-small cell lung cancer (NSCLC), squamous cell carcinoma of the head, ovarian cancer and esophageal cancer.

Aufreinigung: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (around aa 191-281) of human ERCC1 protein (exact sequence is proprietary)

Isotyp: IgG2b, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Konservierungsmittel: Azide free

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Details zu ERCC1

Target: ERCC1 (Excision Repair Cross Complementing Polypeptide-1 (ERCC1))

Andere Bezeichnung: ERCC1

Hintergrund:

COFS4, DNA excision repair protein ERCC1, ERCC1, Excision repair cross complementing 1, RAD10, UV20

HeLa or HepG2 cells. Tonsil or Prostate.

Molekulargewicht: 110kDa

Gen-ID: 2067, 435981

Pathways: DNA Reparatur, Production of Molecular Mediator of Immune Response