HMMR Antikörper (AA 1-250)

Produktnummer ABIN7858770

Der Maus Monoklonal anti-HMMR Antikörper wird verwendet zum Nachweis von HMMR in Proben von Human. Er wurde validiert für IHC.

Kurzübersicht für HMMR Antikörper (AA 1-250) (ABIN7858770)

Target: HMMR (Hyaluronan-Mediated Motility Receptor (RHAMM) (HMMR))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser HMMR Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Klon: HMMR-8021

Produktdetails anti-HMMR Antikörper

Bindungsspezifität: AA 1-250

Verwendungszweck: CD168 / RHAMM Antibody

Spezifität: Hyaluronic acid (HA) is a nonsulfated glycosaminoglycan that regulates cell adhesion and migration. HA effects are mediated through two receptors, CD44 (also designated HCAM) and the receptor of hyaluronic acid mediated motility (RHAMM). RHAMM, also designated intracellular hyaluronic acid binding protein (IHABP) and CD168, is a matrix receptor, which is linked to the plasma membrane by a GPI anchor and regulates cell motility. RHAMM expression is upregulated in malignant lymphoid tissues and is subsequently implicated in tumor progression and metastasis formation, as well as signal transduction. Although still unclear, RHAMM is thought to exist as several isoforms ranging in size. A variant isoform, designated v4, is a protein that when over-expressed, is thought to be the cause of transformation and metastasis formation in fibroblasts.

Aufreinigung: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (around aa1-250) of human HMMR protein (exact sequence is proprietary)

Isotyp: IgG1, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Konservierungsmittel: Azide free

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Details zu HMMR

Target: HMMR (Hyaluronan-Mediated Motility Receptor (RHAMM) (HMMR))

Andere Bezeichnung: CD168

Hintergrund:

CD168, CD168 antigen, HMMR, Hyaluronan-mediated motility receptor (RHAMM), IHABP, Intracellular hyaluronic acid-binding protein, Receptor for hyaluronan-mediated motility

breast cancer or placenta.|Human breast

Molekulargewicht: 85-90kDa

Gen-ID: 3161, 728200

UniProt: O75330

Pathways: Glycosaminoglycan Metabolic Process