TFAM Antikörper (AA 1-200)

Produktnummer ABIN7865304

Der Maus Monoklonal anti-TFAM Antikörper (Klon TFAM-9713) (ABIN7865304) detektiert spezifisch TFAM in WB und IHC. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für TFAM Antikörper (AA 1-200) (ABIN7865304)

Target: TFAM (Transcription Factor A, Mitochondrial (TFAM))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser TFAM Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Klon: TFAM-9713

Produktdetails anti-TFAM Antikörper

Bindungsspezifität: AA 1-200

Verwendungszweck: TFAM / TCF6 (Transcription factor A, mitochondrial) / mtTFA Antibody

Spezifität: MtTFA (mitochondrial transcription factor A), also known as mtTF1, TFAM, TCF6 (for transcription factor 6-like1), TCF6L2 and tsHMG, is a nuclear-encoded gene product that is imported into the mitochondria. mtTFA is required for many aspects of mitochondrial biogenesis including the replication and transcription of mitochondrial DNA (mtDNA). In mouse, testis-specific mtTFA is missing the mitochondria targeting sequence and is present in the nucleus rather than the mitochondria. This form of mtTFA is located primarily in the nuclei of elongated spermatids and may be involved in the regulation of gene expression of the haploid male genome. During mouse and human spermatogenesis there is a reduction of mtTFA protein levels and a reduction in mtDNA copy number. These features may provide one of the mechanisms by which paternal mtDNA transmission is prevented. mtTFA has been associated with mitochondrial disorder in humans characterized by ocular myopathy, exercise intolerance and muscle wasting.

Aufreinigung: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (around aa1-200) of human TFAM protein (exact sequence is proprietary)

Isotyp: IgG, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Haltbarkeit: 24 months

Details zu TFAM

Target: TFAM (Transcription Factor A, Mitochondrial (TFAM))

Andere Bezeichnung: TFAM

Hintergrund:

TCF6, MTTF1, MTTFA, TCF6L1, TCF6L2, TCF6L3, MTDPS15

HEK293T

Molekulargewicht: 25kDa

Gen-ID: 7019, 642966

UniProt: Q00059

Pathways: Chromatin Binding