KNG1 Antikörper (AA 1-200)

Produktnummer ABIN7858604

Dieser Maus Monoklonal Antikörper detektiert spezifisch KNG1 in IHC. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für KNG1 Antikörper (AA 1-200) (ABIN7858604)

Target: KNG1 (Kininogen 1 (KNG1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser KNG1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Klon: KNG1-7424

Produktdetails anti-KNG1 Antikörper

Bindungsspezifität: AA 1-200

Verwendungszweck: KNG1 / Kininogen 1 (KNG1-Heavy chain) Antibody

Spezifität: Kininogen is a 644 amino acid precursor protein that is expressed by the KNG1 gene and is secreted into blood plasma. Due to alternative splicing events, several Kininogen protein derivatives exist, including Kininogen LC and Kininogen HC, both of which are produced from the Kininogen precursor and exhibit different functions throughout the cell. Kininogen HC plays an important role in blood coagulation by helping to ensure that prekallikrein and Factor XI (both of which are involved in blood coagulation) are properly situated for interaction with Factor XII. Kininogen HC releases a smaller, active protein known as bradykinin, which plays a role in smooth muscle contraction, induction of hypotension, regulation of blood glucose levels, stimulation of nociceptors and overall mediation of inflammatory responses throughout the cell. In contrast to Kininogen HC, which is involved in blood clotting, Kininogen LC is primarily associated with inhibition of thrombocyte aggregation and also functions as a strong inhibitor of cysteine proteinases.

Aufreinigung: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (around aa1-200) of human KNG1 protein (exact sequence is proprietary)

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Konservierungsmittel: Azide free

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Details zu KNG1

Target: KNG1 (Kininogen 1 (KNG1))

Andere Bezeichnung: KNG1

Hintergrund:

Alpha-2-thiol proteinase inhibitor, BDK, BK, Bradykinin included, Fitzgerald factor, FLAUJEAC FACTOR, HMW kininogen, Ile-Ser-Bradykinin, Kallidin I, Kallidin II, LMW growth-promoting factor, Williams-Fitzgerald-Flaujeac factor

Distinct positivity in plasma and in several cases extracellular matrix along with cytoplasmic expression in kidney.

Molekulargewicht: 64 kDa (heavy chain), 53 kDa (light chain)

Gen-ID: 3827, 77741

Pathways: ACE Inhibitor Pathway, Glycosaminoglycan Metabolic Process