Kallikrein 4 Antikörper (AA 1-200)

Produktnummer ABIN7858589

Dieser Maus Monoklonal Antikörper detektiert spezifisch Kallikrein 4 in IHC. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für Kallikrein 4 Antikörper (AA 1-200) (ABIN7858589)

Target: Kallikrein 4 (KLK4) (Kallikrein-Related Peptidase 4 (KLK4))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Kallikrein 4 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Klon: KLK4-8941

Produktdetails anti-Kallikrein 4 Antikörper

Bindungsspezifität: AA 1-200

Verwendungszweck: KLK4 / Kallikrein related peptidase 4 Antibody

Spezifität: Kallikreins (KLKs) belong to the serine protease family of proteolytic enzymes. Human pancreatic/renal KLK encodes for the KLK1 enzyme, which is involved in post-translational processing of polypeptide precursors. The function of the other members of KLK gene family is still currently unknown, but evidence suggests that many KLKs are implicated in carcinogenesis. The human KLK gene family consists of 15 serine proteases. The human KLK genes are clustered on chromosome 19q13. Unlike other kalllikreins, the KLK4-15 encoded proteases are less related and do not contain a conventional KLK loop. Clusters of genes exhibit high prostatic (KLK2-4, KLK15) or pancreatic (KLK6-13) expression. KLK2 is also known as glandular kallikrein 2, tissue kallikrein, or HGK-1 and KLK3 is known as prostate-specific antigen (PSA). Both KLK2 and KLK3 have important applications in prostate cancer and breast cancer diagnostics. Many of the KLKs are regulated by steroid hormones and a few of them, specifically KLK3, KLK6 and KLK10, are known to be downregulated in breast and other cancers. KLK4 expression is abundant in skin, mammary gland and testis.

Aufreinigung: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment of human KLK4 protein (around aa 1-200) (exact sequence is proprietary)

Isotyp: IgG1, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Haltbarkeit: 24 months

Details zu Kallikrein 4

Target: Kallikrein 4 (KLK4) (Kallikrein-Related Peptidase 4 (KLK4))

Andere Bezeichnung: KLK4

Hintergrund:

7S nerve growth factor alpha chain, AI2A1, Alpha-NGF, Androgen-regulated message 1, ARM1, EC 3.4.21.-, EMSP1, Enamel Matrix Serine Protease 1, HK4, Kallikrein 4, Kallikrein L1, Kallikrein like protein 1, Kallikrein related-peptidase 4 (prostase, enamel matrix, prostate), KLK-L1, KLK4, Protease Serine 17, PRSS17, PSTS, Serine protease 17

Human skin tissue (IHC). MCF-7 cell lysates.

Molekulargewicht: 28-37kDa

Gen-ID: 9622, 218366

UniProt: Q9Y5K2

Pathways: Komplementsystem