FAP Antikörper (AA 1-200)

Produktnummer ABIN7862798

Dieser Maus Monoklonal Antikörper detektiert spezifisch FAP in IHC. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für FAP Antikörper (AA 1-200) (ABIN7862798)

Target: FAP (Fibroblast Activation Protein, alpha (FAP))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser FAP Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Klon: FAP-4854

Produktdetails anti-FAP Antikörper

Bindungsspezifität: AA 1-200

Verwendungszweck: Fibroblast Activation Protein Alpha / FAP-1 Antibody

Spezifität: FAP (fibroblast activation protein) is a cell surface glycoprotein and serine protease that is expressed primarily in fetal mesenchymal tissues and epithelial cancer fibroblasts. In cancer, FAP functions to promote cellular proliferation. In embryonic development, FAP functions to remodel developing tissues. FAP acts as an integral membrane gelatinase composed of N-glycosylated proteolytically inactive subunits. FAP expression on chondrocyte membranes is upregulated by the combination of the cytokines IL-1 and OSM and has been shown to increase in osteoarthritic patients. This expression is colocalized with MMP-1 and MMP-13 as well as CD44 (variants v3 and v7/8). Mice that lack all copies of the FAP gene have been found to be fertile and to have developmental defects or change in cancer susceptibility.

Aufreinigung: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment (around aa 1-200) of human FAP protein (exact sequence is proprietary)

Isotyp: IgG2c, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Haltbarkeit: 24 months

Details zu FAP

Target: FAP (Fibroblast Activation Protein, alpha (FAP))

Andere Bezeichnung: Fibroblast Activation Protein Alpha

Hintergrund:

170 kDa melanoma membrane-bound gelatinase, DPPIV, FAP, FAPA, Fibroblast activation protein alpha, Integral membrane serine protease, Seprase

Human uterus, colon or pancreas. Fibroblast specific.

Molekulargewicht: 88kDa

Gen-ID: 2191, 654370

UniProt: Q12884

Pathways: Tube Formation