Rekombinanter Progesterone Receptor Antikörper (AA 1-200)

Produktnummer ABIN7863236

Der Kaninchen Monoklonal anti-Progesterone Receptor Antikörper wird verwendet zum Nachweis von Progesterone Receptor in Proben von Human und Pferd. Er wurde validiert für IHC.

Kurzübersicht für Rekombinanter Progesterone Receptor Antikörper (AA 1-200) (ABIN7863236)

Target: Progesterone Receptor (PGR)

Antikörpertyp: Recombinant Antibody

Reaktivität: Human, Pferd

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser Progesterone Receptor Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Klon: PGR-6854R

Produktdetails anti-Progesterone Receptor Antikörper

Bindungsspezifität: AA 1-200

Expressionssystem: HEK-293 Cells

Verwendungszweck: Recombinant Progesterone Receptor (Marker of Progestin Dependence) Antibody

Spezifität: Progesterone is one of the central regulators of female reproduction. In breast development, progesterone is involved in the formation of lobular-alveolar structures and also affects differentiation in the breast by modulation of milk protein synthesis. The cellular effects of progesterone are mediated through progesterone receptors (PR). PR, a protein with 946 amino acids, is a ligand-activated transcription factor member of the steroid receptor super family of nuclear receptors. PR is predominantly expressed in female sex steroid responsive tissues such as the mammary gland, uterus and ovary but is also found in other tissues such as endocrine cells of the Langerhans' islets. The estrogen receptor (ER) and PR status has been used for over 20 years as a predictor of breast carcinoma responsiveness to endocrine therapy and as a prognostic indicator for early recurrence.

Aufreinigung: 200ug/ml of Ab produced in HEK293 cell mammalian-based expression system.

Immunogen: Recombinant fragment (around aa 1-200) of human PGR (exact sequence is proprietary)

Isotyp: IgG, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Haltbarkeit: 24 months

Details zu Progesterone Receptor

Target: Progesterone Receptor (PGR)

Andere Bezeichnung: Progesterone Receptor

Hintergrund:

NR3C3, Nuclear receptor subfamily 3 group C member 3, PGR, PR, PRA, PRB, Progesterone receptor form A, Progesterone receptor form B

Human breast carcinoma.

Molekulargewicht: PR-A (81kDa) and PR-B (116kDa).

Gen-ID: 5241, 2905

UniProt: P06401

Pathways: Nuclear Receptor Transcription Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Smooth Muscle Cell Migration