Rekombinanter Endoglin Antikörper

Produktnummer ABIN7857784

Der Maus Monoklonal anti-Endoglin Antikörper (Klon r4G11) (ABIN7857784) detektiert spezifisch Endoglin in WB und IHC. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für Rekombinanter Endoglin Antikörper (ABIN7857784)

Target: Endoglin (ENG)

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Endoglin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Klon: R4G11

Produktdetails anti-Endoglin Antikörper

Expressionssystem: CHO Cells

Verwendungszweck: Recombinant Endoglin / CD105 (Angiogenesis Marker) Antibody

Spezifität: CD105/Endoglin is a Type I membrane glycoprotein located on cell surfaces and is part of the TGF-beta receptor complex. This protein has been found on endothelial cells, activated macrophages, fibroblasts, and smooth-muscle cells. Endoglin has a role in the development of the cardiovascular system and in vascular remodeling. Its expression is regulated during heart development. CD105 is highly expressed in endothelial cells during tumor angiogenesis and inflammation, with weak or negative expression in vascular endothelium of normal tissues. Angiogenesis is a promising prognostic marker in a variety of tumors. Endoglin is a more specific and sensitive marker for tumor angiogenesis than CD31 or CD34, as it labels only newly-formed blood vessels and may serve as a prognostic marker for Prostate Adenocarcinoma, and cancers of the lung, stomach, breast, and brain.

Aufreinigung: 200ug/ml of Ab produced in CHO cell mammalian-based expression system.

Immunogen: Prokaryotic recombinant protein corresponding to a region of the external domain of the CD105 glycoprotein

Isotyp: IgG2a, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Konservierungsmittel: Azide free

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Details zu Endoglin

Target: Endoglin (ENG)

Andere Bezeichnung: Endoglin

Hintergrund:

CD105, END, Endoglin, Eng, HHT1, S-endoglin

HeLa, A431 or HL-60 cells. Human placenta or brain.

Molekulargewicht: 80kDa (Monomer), 160kDa (Homodimer)

Gen-ID: 2022, 76753

UniProt: P17813