Rekombinanter PVRL4 Antikörper (Extracellular Domain)

Produktnummer ABIN7865529

Der Kaninchen Monoklonal anti-PVRL4 Antikörper wird verwendet zum Nachweis von PVRL4 in Proben von Human. Er wurde validiert für IHC und FACS.

Kurzübersicht für Rekombinanter PVRL4 Antikörper (Extracellular Domain) (ABIN7865529)

Target: PVRL4 (Poliovirus Receptor-Related 4 (PVRL4))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser PVRL4 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Flow Cytometry (FACS)

Klon: NECTIN4-13438R

Produktdetails anti-PVRL4 Antikörper

Bindungsspezifität: AA 266-280, Extracellular Domain

Expressionssystem: CHO Cells

Verwendungszweck: Recombinant Nectin 4 / Nectin Cell Adhesion Molecule 4 / PVRL4 Antibody

Spezifität: Homologous to the poliovirus receptor (PVR/CD155), the nectin immunoglobulin superfamily comprises four known isoforms (-1, -2, -3, and -4). The ectodomain of nectin family members comprises three Ig-like domains (V, C, C). Nectins localize at the adherens junctions (AJ) in epithelial and endothelial cells where they serve as adhesion molecules. Actin-based AJs play a role in mechanical adhesion, cellular morphogenesis and cellular differentiation. Nectin associates with the Actin cytoskeleton through its interaction with the Actin filament-binding protein afadin. Nectin 4 and afadin co-localize at cadherin-based adherens junctions in MDCKII epithelial cells. Nectin 4 and Nectin 3 share a common binding region in the V domain of Nectin 1 and thus compete for Nectin 1 binding. The Nectin 3/4 binding domain maps to the C-C'-C''-D b strands of the V domain of Nectin 1. Unlike other nectins, which are more widely expressed, Nectin 4 is mainly expressed in the placenta.

Aufreinigung: 200ug/ml of Ab produced in CHO cell mammalian-based expression system.

Immunogen: Recombinant fragment (around aa266-280) of human NECTIN4 protein corresponding to the extracellular domain (exact sequence is proprietary)

Isotyp: IgG, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Haltbarkeit: 24 months

Details zu PVRL4

Target: PVRL4 (Poliovirus Receptor-Related 4 (PVRL4))

Andere Bezeichnung: Nectin 4

Hintergrund:

Ig superfamily receptor LNIR family, Nectin 4, poliovirus receptor-related 4, Processed poliovirus receptor-related protein 4, PRR4, PVRL4

Human tonsil, placenta or breast. MCF-7 or T47D cells.

Molekulargewicht: 66kDa

Gen-ID: 81607, 492490

UniProt: Q96NY8

Pathways: Cell-Cell Junction Organization