Rekombinanter Decorin Antikörper (AA 212-336)

Produktnummer ABIN7862694

Dieser Kaninchen Monoklonal Antikörper detektiert spezifisch Decorin in IHC. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für Rekombinanter Decorin Antikörper (AA 212-336) (ABIN7862694)

Target: Decorin (DCN)

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser Decorin Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Klon: DCN-7031R

Produktdetails anti-Decorin Antikörper

Bindungsspezifität: AA 212-336

Expressionssystem: CHO Cells

Verwendungszweck: Recombinant Decorin Antibody

Spezifität: Decorin is a small leucine-rich proteoglycan (SLRP) family member that consists of a glycosaminoglycan chain-containing core protein. The core protein contains ten leucine rich repeats that contain sites for glycosylation, flanked by disulfide bond stabilizing loops. Decorin binds to Collagen Type I, II and IV in vivo and promotes the formation of fibers with variations in stability and solubility. The Decorin core protein binds to growth factors, intercellular matrix molecules, such as Fibronectin and Thrombospondin, and to the Decorin endocytosis receptor. Decorin binds to and inhibits TGF æ and is a direct or indirect negative modulator of TGF æ synthesis. Inhibition of Decorin core protein gene expression by the combination of IFN-Á and TNF°™ may contribute to cartilage destruction that is characteristic of inflammatory joint diseases. For immunostaining, pre-incubation with chondroitinase-SBC or testicular hyaluronidase may be required to expose the epitope.

Aufreinigung: 200ug/ml of Ab produced in CHO cell mammalian-based expression system.

Immunogen: Recombinant human Decorin protein fragment (around aa212-336) (exact sequence is proprietary)

Isotyp: IgG, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Haltbarkeit: 24 months

Details zu Decorin

Target: Decorin (DCN)

Andere Bezeichnung: Decorin

Hintergrund:

Bone proteoglycan II, CSCD, Dermatan sulphate proteoglycans II (DSPG2), PG40, PGII, PGS2, Proteoglycan core protein, SLRR1B, Small leucine rich protein 1B

Human prostate or skin tissue (IHC).

Molekulargewicht: 43kDa

Gen-ID: 1634, 728830

UniProt: P07585

Pathways: Glycosaminoglycan Metabolic Process