MERTK Antikörper

Produktnummer ABIN7828913

Der Maus Monoklonal anti-MERTK Antikörper wird verwendet zum Nachweis von MERTK in Proben von Human. Er wurde validiert für FACS.

Kurzübersicht für MERTK Antikörper (ABIN7828913)

Target: MERTK (C-Mer Proto-Oncogene Tyrosine Kinase (MERTK))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser MERTK Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS)

Klon: 590H11G1E3

Produktdetails anti-MERTK Antikörper

Verwendungszweck: Purified Anti-Human MER Antibody[590H11G1E3]

Aufreinigung: >98%, Protein A/G purified

Reinheit: >98 %

Immunogen: Recombinant Human MER protein

Isotyp: IgG1, kappa

Anwendungsinformationen

Applikationshinweise: FCM 2 μg/mL(0.5x106-1x106 cells)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: ≥ 1 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.05 % non-protein stabilizer. Dialyze to completely remove the stabilizer prior to labeling.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles.

Haltbarkeit: 12 months

Details zu MERTK

Target: MERTK (C-Mer Proto-Oncogene Tyrosine Kinase (MERTK))

Andere Bezeichnung: MER

Hintergrund: Tyro,MERTK,MER,RP38,Tyro12,c-Eyk,c-mer,Proto-oncogene c-Mer,Receptor tyrosine kinase MerTK,Tyrosine-protein kinase Mer,MERTK plays a role in the retinal pigment epithelium as a regulator of rod outer segments fragments phagocytosis. MERTK also plays a role in the inhibition of Toll-like receptor-mediated innate immune responses through the activation of STAT1. Upregulation of MERTK seems to also promote the survival of certain cancer cells, such as t(1,19)-positive acute lymphoblastic leukemias (ALL). MERTK also has a role in cellular migration, as MERTK KO macrophages demonstrate cytoskeletal disruptions that impacts its shape and directional migration. Melanoma cells express high levels of MERTK, which makes this molecule an attractive therapeutic target. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [

UniProt: Q12866

Pathways: RTK Signalweg