Rekombinanter YAP1 Antikörper (pSer127)

Produktnummer ABIN7828681

Dieser Kaninchen Monoklonal Antikörper detektiert spezifisch YAP1 in WB, IHC, IF und FACS. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für Rekombinanter YAP1 Antikörper (pSer127) (ABIN7828681)

Target: YAP1 (Yes-Associated Protein 1 (YAP1))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser YAP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS)

Klon: A804

Produktdetails anti-YAP1 Antikörper

Bindungsspezifität: pSer127

Verwendungszweck: Recombinant Phospho-YAP1 (Ser127) Monoclonal Antibody

Aufreinigung: Protein A purified

Immunogen: phosphorylated human YAP1 (Ser1270) peptide

Isotyp: IgG, kappa

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000,IHC 1:100-1:200,IF 1:50,FCM 1:50-1:100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Haltbarkeit: 12 months

Details zu YAP1

Target: YAP1 (Yes-Associated Protein 1 (YAP1))

Andere Bezeichnung: YAP1

Hintergrund: COB,COB1,YAP,YAP2,YAP65,YKI,YAP1,65 kDa Yes associated protein,65 kDa Yes-associated protein,Basic protease inhibitor,BPTI,Pancreatic Trypsin Inhibitor,Trasylol,YAp 1,YAP 65,Yes associated protein 1,Yes associated protein 1 65 kDa,Yes associated protein 2,yes associated protein beta,yes -associated protein delta,Yorkie homolog,Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein. Plays a key role to control cell proliferation in response to cell contact. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [

Molekulargewicht:

Calculated MW: 54 kDa

Observed MW: 70-100 kDa The actual band is not consistent with the expectation.

UniProt: P46937

Pathways: MAPK Signalweg, Stem Cell Maintenance, Regulation of Lipid Metabolism by PPARalpha