Rekombinanter VTCN1 Antikörper

Produktnummer ABIN7828665

Der Kaninchen Monoklonal anti-VTCN1 Antikörper (Klon A588) (ABIN7828665) detektiert spezifisch VTCN1 in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für Rekombinanter VTCN1 Antikörper (ABIN7828665)

Target: VTCN1 (V-Set Domain Containing T Cell Activation Inhibitor 1 (VTCN1))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser VTCN1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: A588

Produktdetails anti-VTCN1 Antikörper

Verwendungszweck: Recombinant B7-H4 Monoclonal Antibody

Aufreinigung: Protein A purified

Immunogen: Recombinant human B7-H4 fragment

Isotyp: IgG, kappa

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Haltbarkeit: 12 months

Details zu VTCN1

Target: VTCN1 (V-Set Domain Containing T Cell Activation Inhibitor 1 (VTCN1))

Andere Bezeichnung: B7-H4

Hintergrund: B7S,PRO,UNQ,VTCN,B7-H,VCTN,B7h,VTCN1,B7-H4,B7H4,B7S1,B7X,B7h.5,PRO1291,VCTN1,UNQ659,B7H4T-cell costimulatory molecule B7x,B7S1VCTN1,B7XPRO1291,FLJ22418,Immune costimulatory protein B7-H4,Protein B7S1,T cell costimulatory molecule B7x,V-set domain containing T cell activation inhibitor 1,V-set domain-containing T-cell activation inhibitor 1,B7 homolog 4 (B7-H4), also known as VTCN1, is a member of the B7 family of cell surface ligands that regulate T cell activation and immune responses. B7-H4 protein contains two extracellular Ig-like V-type domains, a transmembrane domain, and a short, two amino acid intracellular domain. The B7-H4 protein is shown to inhibit T cell activation, proliferation, and cytokine production. Although B7-H4 mRNA is widely expressed, B7-H4 protein is restricted to antigen presenting cells and B cells. The B7-H4 protein is also found in several tumor types, including ovarian cancer and breast cancer. Research studies indicate that B7-H4 protein is present on the surface of ovarian tumor cells, and that targeted inhibition of B7-H4 using recombinant antibodies restores T cell activation pathways. These studies suggest some potential therapeutic value in blocking B7-H4 function and restoring T cell function in cancer patients. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [

Molekulargewicht:

Calculated MW: 20, 31 kDa

Observed MW: 45, 65 kDa The actual band is not consistent with the expectation.

UniProt: Q7Z7D3