Rekombinanter SMC1A Antikörper

Produktnummer ABIN7828589

Der Kaninchen Monoklonal anti-SMC1A Antikörper wird verwendet zum Nachweis von SMC1A in Proben von Human und Maus. Er wurde validiert für WB.

Kurzübersicht für Rekombinanter SMC1A Antikörper (ABIN7828589)

Target: SMC1A (Structural Maintenance of Chromosomes 1A (SMC1A))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser SMC1A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: A706

Produktdetails anti-SMC1A Antikörper

Verwendungszweck: Recombinant SMC1A Monoclonal Antibody

Aufreinigung: Protein A purified

Isotyp: IgG, kappa

Anwendungsinformationen

Applikationshinweise: WB 1:1000-1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Haltbarkeit: 12 months

Details zu SMC1A

Target: SMC1A (Structural Maintenance of Chromosomes 1A (SMC1A))

Andere Bezeichnung: SMC1A

Hintergrund: SMC,CDLS,KIAA,SMC1L,SMC1A,CDLS2,DXS423E,SB1.8,SMC1,SMC1L1,SMC1alpha,SMCB,KIAA0178,Chromosome segregation protein SmcB,MGC138332,Segregation of mitotic chromosomes 1,SMC protein 1A,SMC1 (structural maintenance of chromosomes 1 yeast) like 1,SMC1 structural maintenance of chromosomes 1 like 1,SMC-1A,SMC-1-alpha,Structural maintenance of chromosomes 1A,Structural maintenance of chromosomes protein 1A,he cohesin complex consists of a heterodimer between SMC1 (SMC1A or B) and SMC3, bound by additional RAD21 and STAG proteins (STAG1, 2, or 3). These proteins form a ring-like structure that mediates the cohesion of two sister chromatids after DNA replication in S phase. RAD21 and STAG2 are phosphorylated by Polo-like kinase (PLK) during prophase, which leads to the dissociation of cohesin complexes from the chromosome arms, however, cohesin remains bound to centromeres until anaphase. RAD21 is cleaved by separin/ESPL1 in anaphase, which leads to dissociation of the remaining cohesin from centromeres, enabling sister chromatids to segregate during mitosis. RAD21 is also cleaved by caspase-3 and caspase-7 during apoptosis, resulting in a 64 kDa carboxy-terminal cleavage product that translocates to the cytoplasm and may help to trigger apoptosis. In addition to mediating cohesion of sister chromatids, the cohesin complex plays important roles in gene regulation and DNA repair, as SMC1 and SMC3 are both phosphorylated by ATM and ATR kinases upon DNA damage. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [

Molekulargewicht:

Calculated MW: 141 kDa

Observed MW: 160 kDa The actual band is not consistent with the expectation.

UniProt: Q14683

Pathways: Stem Cell Maintenance