Rekombinanter RUNX3 Antikörper

Produktnummer ABIN7828537

Dieser Kaninchen Monoklonal Antikörper detektiert spezifisch RUNX3 in WB und IP. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für Rekombinanter RUNX3 Antikörper (ABIN7828537)

Target: RUNX3 (Runt-Related Transcription Factor 3 (RUNX3))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser RUNX3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP)

Klon: A518

Produktdetails anti-RUNX3 Antikörper

Verwendungszweck: Recombinant RUNX3 Monoclonal Antibody

Aufreinigung: Protein A purified

Immunogen: Recombinant human RUNX3 fragment

Isotyp: IgG, kappa

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:1000,IP 1:25-1:50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Haltbarkeit: 12 months

Details zu RUNX3

Target: RUNX3 (Runt-Related Transcription Factor 3 (RUNX3))

Andere Bezeichnung: RUNX3

Hintergrund: AML,RUNX,CBFA,Oncogene AML,Core-binding factor subunit alpha,Runt-related transcription factor,PEBP2A,RUNX3,AML2,CBFA3,PEBP2aC,Acute myeloid leukemia 2 protein,Core-binding factor subunit alpha-3,Oncogene AML-2,Runt-related transcription factor 3,PEBP2A3,RUNX3 is a member of the Runt family of transcription factors, playing an important role in the suppression of gastric epithelium cell proliferation, dorsal root ganglia neurogenesis, and T cell differentiation. RUNX3 is also involved in Caspase-3-dependent apoptosis. Protein complexes containing RUNX3 and various transcription factors, such as Smads or β-catenin/TCF4, have tumor suppressor activity and regulate downstream target gene transcription. While typically localized to the nucleus, RUNX3 can be tyrosine phosphorylated and located in the cytoplasm of many cancer cells. This mislocalization of RUNX3 abolishes its tumor suppressor function and contributes to tumorigenesis. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [

Molekulargewicht:

Calculated MW: 46 kDa

Observed MW: 44-46 kDa The actual band is not consistent with the expectation.

UniProt: Q13761