Rekombinanter PLAG1 Antikörper

Produktnummer ABIN7828465

Dieser Kaninchen Monoklonal Antikörper detektiert spezifisch PLAG1 in WB und IHC. Es zeigt Reaktivität gegenüber Proben von Human, Maus und Ratte.

Kurzübersicht für Rekombinanter PLAG1 Antikörper (ABIN7828465)

Target: PLAG1 (Pleiomorphic Adenoma Gene 1 (PLAG1))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser PLAG1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Klon: A660

Produktdetails anti-PLAG1 Antikörper

Verwendungszweck: Recombinant PLAG1 Monoclonal Antibody

Aufreinigung: Protein A purified

Immunogen: Recombinant human PLAG1 fragment

Isotyp: IgG, kappa

Anwendungsinformationen

Applikationshinweise: WB 1:5000-1:10000,IHC 1:50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Haltbarkeit: 12 months

Details zu PLAG1

Target: PLAG1 (Pleiomorphic Adenoma Gene 1 (PLAG1))

Andere Bezeichnung: PLAG1

Hintergrund: ZNF,Zinc finger protein PLAG,Pleiomorphic adenoma gene,FGFR1/PLAG1 fusion variant,PLAG,COL1A2/PLAG1 fusion,FGFR1/PLAG1 fusion variant 3,Pleiomorphic adenoma gene 1,Pleiomorphic adenoma gene 1 protein,PSA,SGPA,Zinc finger protein PLAG1,ZNF912,PLAG1,PSA,SGPA,Pleiomorphic adenoma gene 1 protein (PLAG1) is a transcription factor whose activation results in up-regulation of target genes, such as IGFII, leading to uncontrolled cell proliferation. When PLAG1 overexpression in cultured cells, higher proliferation rate and transformation are observed. Other target genes such as CRLF1, CRABP2, CRIP2, PIGF are strongly induced in cells with PLAG1 induction. PLAG1 ectopic expression can trigger the development of pleomorphic adenomas of the salivary gland and lipoblastomas. PLAG1 overexpression is associated with up-regulation of IGFII, is frequently observed in hepatoblastoma, common primary liver tumor in childhood. PLAG1 cooperates with CBFB-MYH11, a fusion gene important for myeloid leukemia. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [

Molekulargewicht:

Calculated MW: 56 kDa

Observed MW: 56 kDa

UniProt: Q6DJT9