Rekombinanter MAP2K5 Antikörper

Produktnummer ABIN7828398

Der Kaninchen Monoklonal anti-MAP2K5 Antikörper (Klon A623) (ABIN7828398) detektiert spezifisch MAP2K5 in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für Rekombinanter MAP2K5 Antikörper (ABIN7828398)

Target: MAP2K5 (Mitogen-Activated Protein Kinase Kinase 5 (MAP2K5))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser MAP2K5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: A623

Produktdetails anti-MAP2K5 Antikörper

Verwendungszweck: Recombinant MEK5 Monoclonal Antibody

Aufreinigung: Protein A purified

Immunogen: Recombinant human MEK5 fragment

Isotyp: IgG, kappa

Anwendungsinformationen

Applikationshinweise: WB 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Haltbarkeit: 12 months

Details zu MAP2K5

Target: MAP2K5 (Mitogen-Activated Protein Kinase Kinase 5 (MAP2K5))

Andere Bezeichnung: MEK5

Hintergrund: MEK,MKK,MAP2K,MAPKK,PRKMK,MAP2K5,HsT17454,MAPKK5,MEK5,PRKMK5,MKK5,Dual specificity mitogen activated protein kinase kinase 5,Dual specificity mitogen-activated protein kinase kinase 5,EC 2.7.12.2,kinase 5,MAP kinase kinase 5,MAP kinase kinase MEK5b,MAPK/ERK kinase 5,MAPKK 5,MEK 5,mitogen-activated,mitogen-activated protein kinase kinase 5,MP2K5,Protein kinase,SAPKK5,SKK5,MEK5 is a dual specific kinase that specifically activates ERK5 involved in the regulation of diverse cellular processes, including cell growth, survival, and differentiation. The MEK5-ERK5 pathway is activated in numerous cancer types and plays a role in tumor growth and metastasis. Pharmacological targeting of the MEK5-ERK5 pathway has been investigated as a strategy for cancer treatment. MEK5 is activated by a variety of stimuli, including growth factors, cytokines, and oxidative stress. Activation of MEK5 is triggered by upstream kinases MEKK2 and MEKK3, leading to phosphorylation of MEK5 at Ser311 and Thr315, which subsequently leads to MEK5 dependent phosphorylation of EKR5 at Thr218 and Tyr220. Phosphorylation of ERK5 leads to nuclear translocation and regulation of several oncogenic transcription factors, including MEF2C, c-Fos, c-Myc, and Sap1. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [

Molekulargewicht:

Calculated MW: 49, 50 kDa

Observed MW: 49, 50 kDa

UniProt: Q13163

Pathways: MAPK Signalweg, Neurotrophin Signalübertragung