Rekombinanter HSD17B1 Antikörper

Produktnummer ABIN7828297

Dieser Kaninchen Monoklonal Antikörper detektiert spezifisch HSD17B1 in WB und IHC. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für Rekombinanter HSD17B1 Antikörper (ABIN7828297)

Target: HSD17B1 (Hydroxysteroid (17-Beta) Dehydrogenase 1 (HSD17B1))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser HSD17B1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Klon: A558

Produktdetails anti-HSD17B1 Antikörper

Verwendungszweck: Recombinant HSD17B1 Monoclonal Antibody

Aufreinigung: Protein A purified

Immunogen: Recombinant human HSD17B1 fragment

Isotyp: IgG, kappa

Anwendungsinformationen

Applikationshinweise: WB 1:5000-1:20000,IHC 1:1000-1:5000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Haltbarkeit: 12 months

Details zu HSD17B1

Target: HSD17B1 (Hydroxysteroid (17-Beta) Dehydrogenase 1 (HSD17B1))

Andere Bezeichnung: HSD17B1

Hintergrund: HSD,EDHB,HSD17B,SDR28C,HSD17B1,17-beta-HSD,20-alpha-HSD,E2DH,EDH17B2,EDHB17,HSD17,SDR28C1,E17KSR,EDH17B1,17 beta HSD 1,17 beta hydroxysteroid dehydrogenase type 1,17-beta-HSD 1,17-beta-hydroxysteroid dehydrogenase type 1,20 alpha-hydroxysteroid dehydrogenase,DHB1,Estradiol 17 beta dehydrogenase 1,Estradiol 17-beta-dehydrogenase 1,Hydroxysteroid (17 beta) dehydrogenase 1,member 1,MGC13814,Placental 17 beta hydroxysteroid dehydrogenase,Placental 17-beta-hydroxysteroid dehydrogenase,Short chain dehydrogenase/reductase family 28CE,HSD17B1 is a member of the 17beta-hydroxysteroid dehydrogenase family of short-chain dehydrogenases/reductases. It has a dual function in estrogen activation and androgen inactivation and plays a major role in establishing the estrogen E2 concentration gradient between serum and peripheral tissues. HSD17B1 catalyzes the last step in estrogen activation, using NADPH to convert estrogens E1 and E2 and androgens like 4-androstenedione, to testosterone. It has an N-terminal short-chain dehydrogenase domain with a cofactor binding site, and a narrow, hydrophobic C-terminal domain with a steroid substrate binding site. HSD17B1 is expressed primarily in the placenta and ovarian granulosa cells, and to a lesser extent, in the endometrium, adipose tissue, and prostate. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [

Molekulargewicht:

Calculated MW: 35 kDa

Observed MW: 35 kDa

UniProt: P14061

Pathways: Metabolism of Steroid Hormones and Vitamin D, Steroid Hormone Biosynthesis