Rekombinanter HMGB1 Antikörper

Produktnummer ABIN7828259

Der Kaninchen Monoklonal anti-HMGB1 Antikörper wird verwendet zum Nachweis von HMGB1 in Proben von Human, Maus und Ratte. Er wurde validiert für WB, IHC, FACS und IP.

Kurzübersicht für Rekombinanter HMGB1 Antikörper (ABIN7828259)

Target: HMGB1 (High Mobility Group Box 1 (HMGB1))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser HMGB1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunoprecipitation (IP)

Klon: A253

Produktdetails anti-HMGB1 Antikörper

Verwendungszweck: Recombinant HMGB1 Monoclonal Antibody

Aufreinigung: Protein A purified

Immunogen: Recombinant human HMGB1 fragment

Isotyp: IgG, kappa

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000,IHC 1:200-1:1000,FCM 1:50-1:100,IP 1:25

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Haltbarkeit: 12 months

Details zu HMGB1

Target: HMGB1 (High Mobility Group Box 1 (HMGB1))

Andere Bezeichnung: HMGB1

Hintergrund: SBP,HMGB,High Mobility Group Protein,High mobility group protein B,HMG,HMG-1,HMG1,HMG3,SBP-1,HMGB1,Amphoterin,High Mobility Group Protein 1,High mobility group protein B1,High mobility group protein 1 (HMG-1),High mobility group protein 1,high mobility group protein B1,high-mobility group box 1,HMG1,HMG-1,HMG1DKFZp686A04236,HMG3,HMGB1,SBP-1,Chromosomal protein,DKFZp686A04236,High mobility group 1,High mobility group box 1,high-mobility group (nonhistone chromosomal) protein 1,HMGB 1,nonhistone,NONHISTONE CHROMOSOMAL PROTEIN HMG1,SBP 1,Sulfoglucuronyl carbohydrate binding protein,Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functions as sensor and/or chaperone for immunogenic nucleic acids implicating the activation of TLR9-mediated immune responses, and mediates autophagy. Acts as danger associated molecular pattern (DAMP) molecule that amplifies immune responses during tissue injury. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [

Molekulargewicht:

Calculated MW: 25 kDa

Observed MW: 25 kDa

UniProt: P09429

Pathways: p53 Signalweg, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Toll-Like Receptors Cascades, Smooth Muscle Cell Migration, Inflammasome