Rekombinanter Clusterin Antikörper

Produktnummer ABIN7828120

Dieser Kaninchen Monoklonal Antikörper detektiert spezifisch Clusterin in WB. Es zeigt Reaktivität gegenüber Proben von Ratte und Maus.

Kurzübersicht für Rekombinanter Clusterin Antikörper (ABIN7828120)

Target: Clusterin (CLU)

Antikörpertyp: Recombinant Antibody

Reaktivität: Ratte, Maus

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser Clusterin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: A616

Produktdetails anti-Clusterin Antikörper

Verwendungszweck: Recombinant Clusterin beta Chain Monoclonal Antibody

Aufreinigung: Protein A purified

Immunogen: Recombinant human Clusterin beta Chain fragment

Isotyp: IgG, kappa

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Haltbarkeit: 12 months

Details zu Clusterin

Target: Clusterin (CLU)

Andere Bezeichnung: Clusterin beta Chain

Hintergrund: KUB,AAG,Ku70-binding protein,Sulfated glycoprotein,Complement-associated protein SP,Testosterone-repressed prostate message,NA1/NA,SGP,CLU,AAG4,APO-J,APOJ,CLI,CLU1,CLU2,KUB1,NA1/NA2,SGP-2,SGP2,SP-40,TRPM-2,TRPM2,clusterin,CLUS,Aging-associated gene 4 protein,Apolipoprotein J,Complement cytolysis inhibitor,Complement-associated protein SP-40,Ku70-binding protein 1,Sulfated glycoprotein2,Testosterone-repressed prostate message 2,Complement cytolysis inhibitor a chain,Clusterin alpha chain,Complement cytolysis inhibitor b chain,APOJ CLI,Sulfated glycoprotein 2,Clusterin (CLU) also named as apolipoprotein J, is a multifunctional glycoprotein that is expressed ubiquitously in most tissues. Clusterin functions as a secreted chaperone protein that interacts with and stabilizes stress-induced proteins to prevent their precipitation. Research studies show that clusterin plays a protective role in Alzheimer's disease by sequestering amyloid β (1-40) peptides to form long-lived, stable complexes, which prevents amyloid fibril formation.In addition to the secreted protein, several intracellular isoforms are localized to the nucleus, mitochondria, cytoplasm and ER. The subcellular distribution of these multiple isoforms leads to the diversity of clusterin functions. Additional studies report that clusterin is involved in membrane recycling, cell adhesion, cell proliferation, apoptosis, and tumor survival. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [

Molekulargewicht:

Calculated MW: 52 kDa

Observed MW: 35 kDa The actual band is not consistent with the expectation.

UniProt: P10909

Pathways: Apoptose, Negative Regulation of intrinsic apoptotic Signaling