Rekombinanter CHD1 Antikörper

Produktnummer ABIN7828112

Der Kaninchen Monoklonal anti-CHD1 Antikörper wird verwendet zum Nachweis von CHD1 in Proben von Human und Maus. Er wurde validiert für WB.

Kurzübersicht für Rekombinanter CHD1 Antikörper (ABIN7828112)

Target: CHD1 (Chromodomain Helicase DNA Binding Protein 1 (CHD1))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser CHD1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: A646

Produktdetails anti-CHD1 Antikörper

Verwendungszweck: Recombinant CHD1 Monoclonal Antibody

Aufreinigung: Protein A purified

Immunogen: Recombinant human CHD1 fragment

Isotyp: IgG, kappa

Anwendungsinformationen

Applikationshinweise: WB 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Haltbarkeit: 12 months

Details zu CHD1

Target: CHD1 (Chromodomain Helicase DNA Binding Protein 1 (CHD1))

Andere Bezeichnung: CHD1

Hintergrund: CHD,chromodomain-helicase-DNA-binding protein,CHD1,chromodomain-helicase-DNA-binding protein 1,CHD1 belongs to the SNF2/RAD54 helicase family. CHD1 is an aTP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. CHD1 regulates polymerase II transcription. It is required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. CHD1 negatively regulates DNA replication. CHD1 is associated with histone deacetylase (HDAC) activity. CHD1 is required for the bridging of SNF2, the FACT complex, the PAF complex as well as the U2 snRNP complex to H3K4me3. It functions to modulate the efficiency of pre-mRNA splicing in part through physical bridging of spliceosomal components to H3K4me3. It is required for maintaining open chromatin and pluripotency in embryonic stem cells. In PTEN-deficient prostate and breast cancers, CHD1 depletion profoundly and specifically suppressed cell proliferation, cell survival and tumorigenic potential. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [

Molekulargewicht:

Calculated MW: 197 kDa

Observed MW: 250 kDa The actual band is not consistent with the expectation.

UniProt: O14646

Pathways: Chromatin Binding