Rekombinanter CD3D Antikörper

Produktnummer ABIN7828082

Der Kaninchen Monoklonal anti-CD3D Antikörper wird verwendet zum Nachweis von CD3D in Proben von Human. Er wurde validiert für WB, IHC, IP, FACS und IF.

Kurzübersicht für Rekombinanter CD3D Antikörper (ABIN7828082)

Target: CD3D (CD3d Molecule, delta (CD3-TCR Complex) (CD3D))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser CD3D Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Flow Cytometry (FACS), Immunofluorescence (IF)

Klon: A525

Produktdetails anti-CD3D Antikörper

Verwendungszweck: Recombinant CD3D Monoclonal Antibody

Aufreinigung: Protein A purified

Immunogen: Recombinant human CD3D fragment

Isotyp: IgG, kappa

Anwendungsinformationen

Applikationshinweise: WB 1:2000-1:10000,IHC 1:200-1:1000,IF 1:50-1:200,FCM 1:50-1:100,IP 1:25-1:50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Haltbarkeit: 12 months

Details zu CD3D

Target: CD3D (CD3d Molecule, delta (CD3-TCR Complex) (CD3D))

Andere Bezeichnung: CD3D

Hintergrund: IMD,CD3D,CD3-DELTA,IMD19,T3D,T-Cell Receptor T3 Delta Chain,T-cell surface glycoprotein CD3 delta chain,T3,CD3 delta,CD3D is a component of the TCR-CD3 complex, which is present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. In addition, CD3D plays an essential role in thymocyte differentiation. It participates in correct intracellular TCR-CD3 complex assembly and surface expression. In absence of a functional TCR-CD3 complex, thymocytes are unable to differentiate properly. It interacts with CD4 and CD8 and thus serves to establish a functional link between the TCR and coreceptors CD4 and CD8, which is needed for activation and positive selection of CD4 or CD8 T-cells. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [

Molekulargewicht:

Calculated MW: 19 kDa

Observed MW: 23 kDa The actual band is not consistent with the expectation.

UniProt: P04234

Pathways: T-Zell Rezeptor Signalweg, CXCR4-mediated Signaling Events