PI4KB Antikörper (AA 394-690)

Produktnummer ABIN7825680

Dieser Kaninchen Polyklonal Antikörper erkennt spezifisch PI4KB in IHC. Er zeigt eine Reaktivität gegenüber Zebrafisch (Danio rerio).

Kurzübersicht für PI4KB Antikörper (AA 394-690) (ABIN7825680)

Target: PI4KB (Phosphatidylinositol 4-Kinase, Catalytic, beta (PI4KB))

Reaktivität: Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PI4KB Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Produktdetails anti-PI4KB Antikörper

Bindungsspezifität: AA 394-690

Verwendungszweck: Anti-Zebrafish PI4KB Antibody

Produktmerkmale: Anti-Zebrafish PI4KB Antibody catalog # AZQ49GP3. Tested in IHC applications. This antibody reacts with Zebrafish.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived zebrafish PI4KB recombinant protein (Position: D394-D690).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Immunohistochemistry, 2-5 μg/mL, Zebrafish

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Details zu PI4KB

Target: PI4KB (Phosphatidylinositol 4-Kinase, Catalytic, beta (PI4KB))

Andere Bezeichnung: PI4KB

Hintergrund: Phosphatidylinositol 4-kinase beta is an enzyme that in humans is encoded by the PI4KB gene. Inositol phospholipids have an important role in intracellular signaling in response to hormones, growth factors and neurotransmitters. Phosphatidylinositol 4-kinase phosphorylates phosphatidylinositol (PI) to phosphatidylinositol-4-phosphate (PIP). In a second step, PIP is further phosphorylated to phosphatidylinositol-4,5-bisphosphate (PIP2), and PIP2 is subsequently hydrolyzed by phospholipase C, producing the two intracellular second messengers, inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). PI4K230, PI4K92 and PI4K55 are three PI4 kinase isoforms that have been characterized and classified according to their molecular weights of 230, 92 and 55 kD. Previously, PI4 kinases were classified into type II and III enzymes. All isoforms are located on distinct membranes and cellular compartments suggesting various tasks. PI4K230 is located at the endoplasmatic reticulum and outer membranes of mitochondria, PI4K92 at the Golgi apparatus and endoplasmatic reticulum, and PI4K55 at the plasma membrane and endosomes. PI4K230 is predominantly expressed in brain and moderately sensitive to wortmannin as well as specifically and irreversibly inhibited by cyclitol derivatives.

Pathways: Inositol Metabolic Process