PVRL4 Antikörper

Produktnummer ABIN7822914

Der Maus-Monoklonal Anti-PVRL4-Antikörper wurde für IHC validiert. Er ist geeignet zum Nachweis von PVRL4 in Proben aus Human. }

Kurzübersicht für PVRL4 Antikörper (ABIN7822914)

Target: PVRL4 (Poliovirus Receptor-Related 4 (PVRL4))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser PVRL4 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Güteklasse: Carrier-free

Klon: NECT4-7271

Produktdetails anti-PVRL4 Antikörper

Verwendungszweck: PVRL4 Antibody / Nectin-4 (BSA and Azide Free)

Aufreinigung: Protein A/G affinity

Immunogen: A portion of amino acids 1-200 from the human protein was used as the immunogen for the PVRL4 antibody.

Isotyp: IgG2a, kappa

Anwendungsinformationen

Applikationshinweise: Immunohistochemistry (FFPE): 1-2ug/ml

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 1 mg/ml in 1X PBS; BSA free, sodium azide free

Konservierungsmittel: Azide free

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the PVRL4 antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.

Details zu PVRL4

Target: PVRL4 (Poliovirus Receptor-Related 4 (PVRL4))

Andere Bezeichnung: Poliovirus Receptor-Related 4

Hintergrund: Homologous to the poliovirus receptor (PVR/CD155), the nectin immunoglobulin superfamily comprises four known isoforms (-1, -2, -3, and -4). The ectodomain of nectin family members comprises three Ig-like domains (V, C, C). Nectins localize at the adherens junctions (AJ) in epithelial and endothelial cells where they serve as adhesion molecules. Actin-based AJs play a role in mechanical adhesion, cellular morphogenesis and cellular differentiation. Nectin associates with the actin cytoskeleton through its interaction with the actin filament-binding protein afadin. Nectin 4 and afadin co-localize at cadherin-based adherens junctions in MDCKII epithelial cells. Nectin 4 and nectin 3 share a common binding region in the V domain of Nectin 1 and thus compete for Nectin 1 binding. The Nectin 3/4 binding domain maps to the C-C strands of the V domain of Nectin 1. Unlike other nectins, which are more widely expressed, Nectin 4 is mainly expressed in the placenta.

UniProt: Q96NY8

Pathways: Cell-Cell Junction Organization