ADRP Antikörper (AA 31-130)

Produktnummer ABIN738606

Dieses Anti-ADRP-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von ADRP in WB, ELISA, IHC (p), IF (p), IF (cc) und IHC (fro). Geeignet für Human und Maus. Dieses Primary Antibody wurde in 4+ Publikationen zitiert.

Kurzübersicht für ADRP Antikörper (AA 31-130) (ABIN738606)

Target: ADRP (PLIN2) (Perilipin 2 (PLIN2))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ADRP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-ADRP Antikörper

Bindungsspezifität: AA 31-130

Kreuzreaktivität: Human, Maus

Homologie: Rat

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from rat ADFP

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-ADRP Antikörper (ABIN738606)

Zhao, Han, Hong, Sun: "Adipose differentiation‑related protein knockdown inhibits vascular smooth muscle cell proliferation and migration and attenuates neointima formation." in: Molecular medicine reports, Vol. 16, Issue 3, pp. 3079-3086, (2018) (PubMed).

Amrutkar, Cansby, Nuñez-Durán, Pirazzi, Ståhlman, Stenfeldt, Smith, Borén, Mahlapuu: "Protein kinase STK25 regulates hepatic lipid partitioning and progression of liver steatosis and NASH." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 29, Issue 4, pp. 1564-76, (2015) (PubMed).

Amrutkar, Cansby, Chursa, Nuñez-Durán, Chanclón, Ståhlman, Fridén, Mannerås-Holm, Wickman, Smith, Bäckhed, Borén, Howell, Mahlapuu: "Genetic Disruption of Protein Kinase STK25 Ameliorates Metabolic Defects in a Diet-Induced Type 2 Diabetes Model." in: Diabetes, Vol. 64, Issue 8, pp. 2791-804, (2015) (PubMed).

Liu, Dai, Liu, Liu, Tang, Wang, Yi, Liu, Jiang, Yang, Yuan: "Oxidized low-density lipoprotein activates adipophilin through ERK1/2 signal pathway in RAW264.7 cells." in: Acta biochimica et biophysica Sinica, Vol. 42, Issue 9, pp. 635-45, (2010) (PubMed).

Details zu ADRP

Target: ADRP (PLIN2) (Perilipin 2 (PLIN2))

Andere Bezeichnung: ADFP

Hintergrund:

Synonyms: ADFP, Adipophilin, Adipose dferentiation related protein, Adipose dferentiation-related protein, Perilipin-2, PLIN2, PLIN2_HUMAN, adipophilin, Adipose dferentiation related protein, ADRP, MGC10598

Background: Milk lipid globules from humans, cows and rats contain a protein identified as adipocyte differentiation-related protein (ADFP) associated with the globule surface membrane material. This protein, previously believed to be specific to adipocytes, was a major constituent of the globule surface and was present in a detergent-insoluble complex that contained stoichiometric amounts of butyrophilin and xanthine oxidase. ADFP (Adipophilin) occurs in a wide range of cultured cell lines, including fibroblasts, endothelial and epithelial cells. In tissues, however, expression of adipophilin is restricted to certain cell types, such as lactating mammary epithelial cells, adrenal cortex cells, Sertoli and Leydig cells of the male reproductive system, and steatosis or fatty change hepatocytes in alcoholic liver cirrhosis. ADFP may be a possible new marker for the identification of specialized differentiated cells containing lipid droplets and for diseases associated with fat-accumulating cells.

Gen-ID: 298199

Pathways: Regulation of Lipid Metabolism by PPARalpha, Lipid Metabolism