SSTR2 Antikörper (AA 211-320)

Produktnummer ABIN738216

Dieses Anti-SSTR2-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von SSTR2 in WB, ELISA und IHC (p). Geeignet für Human und Maus. Dieses Primary Antibody wurde in 2+ Publikationen zitiert.

Kurzübersicht für SSTR2 Antikörper (AA 211-320) (ABIN738216)

Target: SSTR2 (Somatostatin Receptor 2 (SSTR2))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SSTR2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-SSTR2 Antikörper

Bindungsspezifität: AA 211-320

Kreuzreaktivität: Human, Maus

Homologie: Rat,Dog,Cow,Pig,Horse,Chicken,Rabbit,Guinea Pig

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human SSTR2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-SSTR2 Antikörper (ABIN738216)

Sakai, Yonezawa, Yamawaki, Oyamada: "Alteration of somatostatin receptor 2 expression in canine mammary gland tumor." in: The Journal of veterinary medical science / the Japanese Society of Veterinary Science, (2015) (PubMed).

Ruan, Yu, Xu, Zhang, Long, Shen: "Attenuation of stress-induced gastrointestinal motility disorder by gentiopicroside, from Gentiana macrophylla Pall." in: Fitoterapia, Vol. 103, pp. 265-76, (2015) (PubMed).

Details zu SSTR2

Target: SSTR2 (Somatostatin Receptor 2 (SSTR2))

Andere Bezeichnung: SSTR2/Somatostatin Receptor 2

Hintergrund:

Synonyms: Somatostatin receptor type 2, SS-2-R, SS2-R, SS2R, SRIF-1, SSTR2

Background: Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization.

Gen-ID: 6752

UniProt: P30874