Rekombinanter Keratin 5/6 Antikörper (C-Term)

Produktnummer ABIN7795768

Der Kaninchen Monoklonal anti-Keratin 5/6 Antikörper (Klon BLR340M) (ABIN7795768) detektiert spezifisch Keratin 5/6 in WB und FACS. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für Rekombinanter Keratin 5/6 Antikörper (C-Term) (ABIN7795768)

Target: Keratin 5/6 (KRT5/6)

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser Keratin 5/6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS)

Klon: BLR340M

Produktdetails anti-Keratin 5/6 Antikörper

Bindungsspezifität: C-Term

Verwendungszweck: Rabbit anti-Cytokeratin 5/6 Recombinant Monoclonal Antibody [BLR340M]

Aufreinigung: Purified

Immunogen: between 540 and 590 (C-term)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,11000,Flow-Cyt,Fixed in 4 % formaldehyde and permeabilized with 90 % methanol. 1 μL per 1 x 10^6 cells.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 40 μg/mL

Buffer: Phosphate Buffered Saline (PBS) with 0.1 % BSA and 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: 2 - 8 °C

Haltbarkeit: 12 months

Details zu Keratin 5/6

Target: Keratin 5/6 (KRT5/6)

Andere Bezeichnung: Cytokeratin 5/6

Hintergrund: Cytokeratins 5 and 6 are type II cytokeratins and consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. In normal tissue, Cyokeratin 5 is specifically expressed in the basal layer of the epidermis with family member KRT14 while Cytokeratin 6 is expressed with family members KRT16 and/or KRT17 in the filiform papillae of the tongue, the stratified epithelial lining of oral mucosa and esophagus, the outer root sheath of hair follicles, and the glandular epithelia. Cytokeratins 5 and 6 are often referred to together as "CK5/6", and are commonly expressed in various cancers, particularly those originating from epithelial tissues, and their presence is often used as a marker to identify squamous cell carcinomas or tumors with a basal cell-like phenotype [taken from NCBI Entrez Gene (Gene ID: < a href="https://www.ncbi.nlm.nih.gov/gene/3852" class="gene-values" target="_blank">3852 and < a href="https://www.ncbi.nlm.nih.gov/gene/3853" class="gene-values" target="_blank">3853)].

UniProt: P02538, P13647