YTHDF2
Reaktivität: Human
WB, ELISA
Wirt: Kaninchen
Polyclonal
unconjugated
Applikationshinweise
WB,11000,Flow-Cyt,Fixed in 4 % formaldehyde and permeabilized with 90 % methanol. 1 μL per 1 x 10^6 cells.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Liquid
Konzentration
500 μg/mL
Buffer
Phosphate Buffered Saline (PBS) with 0.1 % BSA and 0.09 % Sodium Azide
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
4 °C
Informationen zur Lagerung
2 - 8 °C
Haltbarkeit
12 months
Target
YTHDF2
(YTH Domain Family, Member 2 (YTHDF2))
Andere Bezeichnung
YTHDF2
Hintergrund
YTHDF2 is a member of the YTH-domain containing (YT521-B homology) superfamily which also contains YTHDF1 and YTHDF3. These proteins share a conserved C-terminal YTH domain that specifically interacts with N6-methyladenosine (m6A) modified RNA. The m6A modification is present at internal sites of mRNAs and some non-coding RNAs and plays an important role in mRNA splicing, processing, and stability. YTHDF2 binding appears to promote mRNA degradation, but has minimal effect on translation efficiency. [adapted from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9Y5A9].